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Details for phenotype: Acute myeloid leukemia

EndoNet ID: ENP00774

Name

Acute myeloid leukemia

General information

This phenotype is not pathologic
  • Acute myeloid leukemia (AML) is cancer that starts inside bone marrow, the soft tissue inside bones that helps form blood cells. The cancer grows from cells that would normally turn into white blood cells.

Links to other resources

OMIM 602439
Medline Plus 000542
MeSH term D015470
Disease database 203

Phenotype triggers

  • more activity (high ligand concentration, overexpression) of FLT3
    in hematopoietic_stem_cell
    • Deregulated tyrosine kinase activity has long been implicated in the molecular pathogenesis of cancer, including leukemia, and mutant forms of KIT, ABL, and platelet-derived growth factor receptor (PDGF-R) number among the constitutively activated tyrosine kinases that have been identified as causative factors in specific hematologic malignancies. [1]
    • FMS-like tyrosine kinase-3 (FLT3), a member of the PDGF-R subfamily of receptor tyrosine kinases, is the most recent major addition to this list [1]
    • A number of FLT3 activating mutations have been found in leukemia patients and human leukemia-derived cell lines. [1]
    • FLT3 activating mutations occur in 30% of AML cases and are therefore the most common molecular abnormality in that disease. [1]
Reference