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Details for receptor: frizzled 2

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EndoNet ID: ENR00430

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Synonyms

  • Fz2
  • frizzled 2
  • Fzd2
  • frizzled-2
  • Fz-2
  • hFz2
  • FzE2
  • frizzled homolog 2 (Drosophila)

General information

  • Frizzleds are cell surface receptor for Wnts. [1]

Links to other resources

UniProt Q14332
Ensembl ENST00000315323

Subunit information

Sequence 
QFHGEKGIS IPDHGFCQP ISIPLCTDI 
AYNQTIMPN LLGHTNQED AGLEVHQFY 
PLVKVQCSP ELRFFLCSM YAPVCTVLE 
QAIPPCRSI CERARQGCE ALMNKFGFQ 
WPERLRCEH FPRHGAEQI CVGQNHSED 
GAPALLTTA PPPGLQPGA GGTPGGPGG 
GGAPPRYAT LEHPFHCPR VLKVPSYLS 
YKFLGERDC AAPCEPARP DGSMFFSQE 
ETRFARLWI LTWSVLCCA STFFTVTTY 
LVDMQRFRY PERPIIFLS GCYTMVSVA 
YIAGFVLQE RVVCNERFS EDGYRTVVQ 
GTKKEGCTI LFMMLYFFS MASSIWWVI 
LSLTWFLAA GMKWGHEAI EANSQYFHL 
AAWAVPAVK TITILAMGQ IDGDLLSGV 
CFVGLNSLD PLRGFVLAP LFVYLFIGT 
SFLLAGFVS LFRIRTIMK HDGTKTEKL 
ERLMVRIGV FSVLYTVPA TIVIACYFY 
EQAFREHWE RSWVSQHCK SLAIPCPAH 
YTPRMSPDF TVYMIKYLM TLIVGITSG 
FWIWSGKTL HSWRKFYTR LTNSRHGET 
TV

Binding hormones

    Anatomical structures with this receptor

    • cerebellum

      Induced phenotypes

      • accumulation of intracellular Ca2+ concentration
        • The Fzd2 receptor promotes the accumulation of intracellular Ca concentration. [2]
        • Traumatic brain injury can stimulate activation of the Wnt5a/Fzd2 signaling pathway [2]
        • Activated Wnt5a/Fzd2 signaling plays an important role in calcium overloading process within cells post traumatic brain injury. [2]

    • colon

    • large_intestine

    • ovary

    • pancreas

    • pancreatic_islets

    • lung

    • kidney

    • skeleton_muscle

    • testis

    • thyroid_gland

    Reference