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Details for receptor: Smo

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EndoNet ID: ENR00440

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • Smo
  • smoothened homolog
  • SMO
  • Gx protein
  • SMOH

General information

  • G protein-coupled receptor that probably associates with the patched protein to transduce the hedgehog's proteins signal. [1]
  • The Ptc tumour suppressor functions normally as a transmembrane molecular transporter, which acts indirectly to inhibit Smo activity, possibly through changes in distribution or concentration of a small molecule. [2]

Links to other resources

UniProt Q99835
Ensembl ENST00000249373

Binding hormones

  • IHH
    • Indian hedgehog (Ihh) has two signaling receptors: patched (Ptc) and smoothened (Smo). [3]

Anatomical structures with this receptor

    Reference