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Details for receptor: frizzled 4

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EndoNet ID: ENR00580

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • Fz4
  • frizzled 4
  • FZD4
  • FzE4
  • hFz4
  • frizzled-4

General information

  • Defects in FZD4 are a cause of exudative vitreoretinopathy 1. [1]
  • Frizzleds are cell surface receptor for Wnts. [2]

Links to other resources

UniProt Q9ULV1
Ensembl ENST00000309186

Subunit information

Sequence 
FGDEEERRC DPIRISMCQ NLGYNVTKM 
PNLVGHELQ TDAELQLTT FTPLIQYGC 
SSQLQFFLC SVYVPMCTE KINIPIGPC 
GGMCLSVKR RCEPVLKEF GFAWPESLN 
CSKFPPQND HNHMCMEGP GDEEVPLPH 
KTPIQPGEE CHSVGTNSD QYIWVKRSL 
NCVLKCGYD AGLYSRSAK EFTDIWMAV 
WASLCFIST AFTVLTFLI DSSRFSYPE 
RPIIFLSMC YNIYSIAYI VRLTVGRER 
ISCDFEEAA EPVLIQEGL KNTGCAIIF 
LLMYFFGMA SSIWWVILT LTWFLAAGL 
KWGHEAIEM HSSYFHIAA WAIPAVKTI 
VILIMRLVD ADELTGLCY VGNQNLDAL 
TGFVVAPLF TYLVIGTLF IAAGLVALF 
KIRSNLQKD GTKTDKLER LMVKIGVFS 
VLYTVPATC VIACYFYEI SNWALFRYS 
ADDSNMAVE MLKIFMSLL VGITSGMWI 
WSAKTLHTW QKCSNRLVN SGKVKREKR 
GNGWVKPGK GSETVV

Binding hormones

  • norrin
  • WNT9A
    • Co-immunoprecipitation assays showed that Wnt9a was selectively bound to Frz4, Fzd7, and Frz9. [3]

Anatomical structures with this receptor

    Reference