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Details for receptor: TLR9

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EndoNet ID: ENR00590

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Synonyms

  • toll-like receptor 9
  • TLR9

General information

  • Plasmacytoid dendritic cells express only TLR7 and high levels of TLR9 mRNA. [1]
  • Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motivs present in bacterial DNA. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [2]
  • Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, specially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. [2]

Links to other resources

UniProt Q9NR96
Ensembl ENST00000423623

Subunit information

isoform 1

Sequence 
LGTLPAFLP CELQPHGLV NCNWLFLKS 
VPHFSMAAP RGNVTSLSL SSNRIHHLH 
DSDFAHLPS LRHLNLKWN CPPVGLSPM 
HFPCHMTIE PSTFLAVPT LEELNLSYN 
NIMTVPALP KSLISLSLS HTNILMLDS 
ASLAGLHAL RFLFMDGNC YYKNPCRQA 
LEVAPGALL GLGNLTHLS LKYNNLTVV 
PRNLPSSLE YLLLSYNRI VKLAPEDLA 
NLTALRVLD VGGNCRRCD HAPNPCMEC 
PRHFPQLHP DTFSHLSRL EGLVLKDSS 
LSWLNASWF RGLGNLRVL DLSENFLYK 
CITKTKAFQ GLTQLRKLN LSFNYQKRV 
SFAHLSLAP SFGSLVALK ELDMHGIFF 
RSLDETTLR PLARLPMLQ TLRLQMNFI 
NQAQLGIFR AFPGLRYVD LSDNRISGA 
SELTATMGE ADGGEKVWL QPGDLAPAP 
VDTPSSEDF RPNCSTLNF TLDLSRNNL 
VTVQPEMFA QLSHLQCLR LSHNCISQA 
VNGSQFLPL TGLQVLDLS HNKLDLYHE 
HSFTELPRL EALDLSYNS QPFGMQGVG 
HNFSFVAHL RTLRHLSLA HNNIHSQVS 
QQLCSTSLR ALDFSGNAL GHMWAEGDL 
YLHFFQGLS GLIWLDLSQ NRLHTLLPQ 
TLRNLPKSL QVLRLRDNY LAFFKWWSL 
HFLPKLEVL DLAGNQLKA LTNGSLPAG 
TRLRRLDVS CNSISFVAP GFFSKAKEL 
RELNLSANA LKTVDHSWF GPLASALQI 
LDVSANPLH CACGAAFMD FLLEVQAAV 
PGLPSRVKC GSPGQLQGL SIFAQDLRL 
CLDEALSWD CFALSLLAV ALGLGVPML 
HHLCGWDLW YCFHLCLAW LPWRGRQSG 
RDEDALPYD AFVVFDKTQ SAVADWVYN 
ELRGQLEEC RGRWALRLC LEERDWLPG 
KTLFENLWA SVYGSRKTL FVLAHTDRV 
SGLLRASFL LAQQRLLED RKDVVVLVI 
LSPDGRRSR YVRLRQRLC RQSVLLWPH 
QPSGQRSFW AQLGMALTR DNHHFYNRN 
FCQGPTAE
UniProt Q9NR96-1

Binding hormones

  • Granulin-1
    • Granulins interact with TLR9. [3]
    • Progranulin is cleaved by elastase to yield discrete fragments in vitro that we also identified as interacting partners of TLR9 by tandem mass spectrometry (MS-MS). [3]

Anatomical structures with this receptor

  • spleen

  • lymph_node

  • monocyte

  • dendritic_cell_in_lymphoid_tissues

    Influences

    • positive IFN-alpha
    • positive IFN-beta

  • lung

  • tonsil

  • neutrophil_granulocyte

  • epithelial_cell_with_microvilli

  • cholangiocyte

  • bronchial_epithelial_cell

  • macrophage

    Influences

    • positive IL-1 beta
      • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [4]
Reference