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Details for receptor: Duffy

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EndoNet ID: ENR00678

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Synonyms

  • DARC
  • Fy glycoprotein
  • Glycoprotein D
  • Plasmodium vivax receptor
  • Duffy
  • Duffy antigen/chemokine receptor

General information

  • Duffy antigen acts as a promiscuous receptor for a number of pro-inflammatory CC and CXC chemokines, therefore it is called the Duffy antigen/receptor for chemokines (DARC). [1]
  • It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. [2]
  • Belongs to the G-protein coupled receptor Duffy family. [2]

Links to other resources

UniProt Q16570
Ensembl ENST00000435307

Binding hormones

    Anatomical structures with this receptor

    • endothelial_cell

      Induced phenotypes

      • regulation of leukocyte migration
        • Duffy, expressed in endothelial cells, is a regulator of induced leukocyte trafficking [1]
      • Duffy antigen is a transmembrane N-glycosylated protein present mainly on erythrocytes and endothelial cells. [1]

    • red_blood_cell

      Induced phenotypes

      • chemokine scavenger
        • DARC is an important regulator of inflammatory reactions, acting as a chemokine scavenger on the surface of red blood cells. [1]
      • Duffy antigen is a transmembrane N-glycosylated protein present mainly on erythrocytes and endothelial cells. [1]
    Reference