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Details for receptor: CXCR1

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EndoNet ID: ENR00681

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Synonyms

  • IL-8R A
  • IL-8 receptor type 1
  • IL8RA
  • CXCR1

General information

  • This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. [1]
  • CXCR1 has high affinity for IL-8 only, whereas the other ELR+CXC chemokines GRO-alpha, GRO-beta, GRO-gamma, epithelial-cellderived neutrophil attractant-78 (ENA-78) and neutrophil-activating protein-2 (NAP-2) bind to this receptor with low affinity. [2]

Links to other resources

UniProt P25024
Ensembl ENST00000421691

Subunit information

Sequence 
MSNITDPQM WDFDDLNFT GMPPADEDY 
SPCMLETET LNKYVVIIA YALVFLLSL 
LGNSLVMLV ILYSRVGRS VTDVYLLNL 
ALADLLFAL TLPIWAASK VNGWIFGTF 
LCKVVSLLK EVNFYSGIL LLACISVDR 
YLAIVHATR TLTQKRHLV KFVCLGCWG 
LSMNLSLPF FLFRQAYHP NNSSPVCYE 
VLGNDTAKW RMVLRILPH TFGFIVPLF 
VMLFCYGFT LRTLFKAHM GQKHRAMRV 
IFAVVLIFL LCWLPYNLV LLADTLMRT 
QVIQETCER RNNIGRALD ATEILGFLH 
SCLNPIIYA FIGQNFRHG FLKILAMHG 
LVSKEFLAR HRVTSYTSS SVNVSSNL

Binding hormones

  • IL-8
    • Binding of IL-8 to the receptor causes activation of neutrophils. [1]
  • GCP-2
  • GROalpha
  • GRObeta
  • GROgamma
  • ENA-78
  • NAP-2

Anatomical structures with this receptor

  • neutrophil_granulocyte

  • monocyte

  • killer_cell

  • acidophil_mammotroph_cell_of_anterior_pituitary

    Influences

    • positive PRL
      • CINC/ stimulates PRL secretion from anterior pituitary monolayer cultures in a concentration-dependent manner with a substantioal lag time. [3]

  • acidophil_somatotroph_cell_of_anterior_pituitary

    Influences

    • positive GH
      • CINC/gro stiumaletes GH secretion from anterior pituitary monolayer cultures in a concentration-dependent manner with a substantial lag time. [3]

  • basophil_gonadotroph_cell_of_anterior_pituitary_FSH

    Influences

    • negative FSH
      • CINC/gro suppresses rapid the basal FSH secretion from normal anterior pituitary cells in a concentration-dependent manner. [3]
    • negative LH
      • CINC/gro suppresses rapid the basal LH secretion from normal anterior pituitary cells in a concentration-dependent manner. [3]

  • basophil_corticotroph_cell_of_anterior_pituitary

    Influences

    • positive ACTH
      • CINC/gro stimulates ACTH secretion from anterior pituitary monolayer cultures with a substantial lag time. [3]

  • basophil_thyrotroph_cell_of_anterior_pituitary

Reference