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Details for receptor: FGFR-2

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EndoNet ID: ENR00700

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Synonyms

  • fibroblast growth factor receptor 2
  • FGFR-2
  • keratinocyte growth factor receptor
  • CD332 antigen

General information

  • FGFR-2 plays an important role in the initial stages of oral cancer progression. [1]

Links to other resources

UniProt P21802
Ensembl ENST00000457416

Subunit information

Sequence 
RPSFSLVED TTLEPEEPP TKYQISQPE 
VYVAAPGES LEVRCLLKD AAVISWTKD 
GVHLGPNNR TVLIGEYLQ IKGATPRDS 
GLYACTASR TVDSETWYF MVNVTDAIS 
SGDDEDDTD GAEDFVSEN SNNKRAPYW 
TNTEKMEKR LHAVPAANT VKFRCPAGG 
NPMPTMRWL KNGKEFKQE HRIGGYKVR 
NQHWSLIME SVVPSDKGN YTCVVENEY 
GSINHTYHL DVVERSPHR PILQAGLPA 
NASTVVGGD VEFVCKVYS DAQPHIQWI 
KHVEKNGSK YGPDGLPYL KVLKAAGVN 
TTDKEIEVL YIRNVTFED AGEYTCLAG 
NSIGISFHS AWLTVLPAP GREKEITAS 
PDYLEIAIY CIGVFLIAC MVVTVILCR 
MKNTTKKPD FSSQPAVHK LTKRIPLRR 
QVTVSAESS SSMNSNTPL VRITTRLSS 
TADTPMLAG VSEYELPED PKWEFPRDK 
LTLGKPLGE GCFGQVVMA EAVGIDKDK 
PKEAVTVAV KMLKDDATE KDLSDLVSE 
MEMMKMIGK HKNIINLLG ACTQDGPLY 
VIVEYASKG NLREYLRAR RPPGMEYSY 
DINRVPEEQ MTFKDLVSC TYQLARGME 
YLASQKCIH RDLAARNVL VTENNVMKI 
ADFGLARDI NNIDYYKKT TNGRLPVKW 
MAPEALFDR VYTHQSDVW SFGVLMWEI 
FTLGGSPYP GIPVEELFK LLKEGHRMD 
KPANCTNEL YMMMRDCWH AVPSQRPTF 
KQLVEDLDR ILTLTTNEE YLDLSQPLE 
QYSPSYPDT RSSCSSGDD SVFSPDPMP 
YEPCLPQYP HINGSVKT
UniProt P21802-1

Binding hormones

  • FGF-10
  • FGF-7
  • FGF-1 isoform 1
  • FGF-16
    • The FGFs 9, 16, and 20 subfamily members activated FGFR 1-3c isoforms and FGFR4 with high activity. [2]
  • FGF-20
  • FGF-9
  • FGF-5
    • FGF-5 can bind and induce autophosphorylation of human FGF receptors (FGFR) 1 and 2. [3]

Anatomical structures with this receptor

  • adrenal_cortex

  • cerebral_cortex

    Induced phenotypes

    • regulation of neuron differentiation
      • FGF-2 functions in the control of neuronal cell differentiation but is not essential for proliferation [4]

  • cardiac_muscle

    Induced phenotypes

    • regulation of cell proliferation
      • We can conclude that FGFR1c and FGFR2c are the only FGFRs functionally required in the developing myocardium at this stage of development. [5]
    • Sectioning of these hearts revealed that isoform c of FGFR2 was expressed in the myocardium. [5]

  • endocardium

    • Isoform b of FGFR2 was expressed in the endocardium. [5]
Reference