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Details for receptor: M3

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  • General information
  • Subunits
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00727

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • M3
  • muscarinic acetylcholine receptor M3
  • CHRM3

General information

Links to other resources

UniProt P20309
Ensembl ENST00000448020

Subunit information

Sequence 
MTLHNNSTT SPLFPNISS SWIHSPSDA 
GLPPGTVTH FGSYNVSRA AGNFSSPDG 
TTDDPLGGH TVWQVVFIA FLTGILALV 
TIIGNILVI VSFKVNKQL KTVNNYFLL 
SLACADLII GVISMNLFT TYIIMNRWA 
LGNLACDLW LAIDYVASN ASVMNLLVI 
SFDRYFSIT RPLTYRAKR TTKRAGVMI 
GLAWVISFV LWAPAILFW QYFVGKRTV 
PPGECFIQF LSEPTITFG TAIAAFYMP 
VTIMTILYW RIYKETEKR TKELAGLQA 
SGTEAETEN FVHPTGSSR SCSSYELQQ 
QSMKRSNRR KYGRCHFWF TTKSWKPSS 
EQMDQDHSS SDSWNNNDA AASLENSAS 
SDEEDIGSE TRAIYSIVL KLPGHSTIL 
NSTKLPSSD NLQVPEEEL GMVDLERKA 
DKLQAQKSV DDGGSFPKS FSKLPIQLE 
SAVDTAKTS DVNSSVGKS TATLPLSFK 
EATLAKRFA LKTRSQITK RKRMSLVKE 
KKAAQTLSA ILLAFIITW TPYNIMVLV 
NTFCDSCIP KTFWNLGYW LCYINSTVN 
PVCYALCNK TFRTTFKML LLCQCDKKK 
RRKQQYQQR QSVIFHKRA PEQAL

Binding hormones

  • acetylcholine

Anatomical structures with this receptor

  • oxyntic_cell_of_gastric_gland

    Induced phenotypes

    • positive regulation of gastric acid secretion
      • Cholinergic stimulation of gastric acid secretion is clearly mediated by the M3 receptor. [1]

  • enterochromaffin_like_cell

  • G_cell

  • D_cell_of_gastrointestinal_tract

  • adrenal_medulla

    Influences

    • positive acetylcholine
      • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [2]
Reference