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Details for receptor: sst1

EndoNet ID: ENR00737

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  • sst(1)
  • SSTR1
  • somatostatin receptor 1
  • sst1

General information

  • SSTR1 was colocalized with glucagon in 26% of alpha-cells. [1]
  • SSTR1 was strongly colocalized with insulin in all beta-cells. [1]
  • SSTR1-3 were colocalized in only a few delta-cells, and SSTR4 was absent. [1]
  • Belongs to the seven transmembrane domain receptor family. [2]
  • May heterodimerize with SSTR5.

Links to other resources

UniProt P30872
Ensembl ENST00000455187

Binding hormones

  • somatostatin
    • Works better with SST-14 than with SST-28.
  • somatostatin-14
  • somatostatin-28
  • cortistatin
    • CST-17 and its rodent homologue CST-14 both bind nonselectively and with nanomolar affinities to all five somatostatin receptor subtypes in vitro. [3]

Anatomical structures with this receptor

  • brain

  • pituitary_gland_of_diencephalon

  • stomach

  • kidney

  • beta_cell_of_islet_of_Langerhans


    • negative insulin
      • Subtype-selective SSTR expression in islet cells could be the basis for preferential insulin suppression by SSTR1-specific ligands. [1]
  • alpha_cell_of_islet_of_Langerhans

  • D_cell


    • negative somatostatin
  • zymogenic_cell_of_gastric_gland

    Induced phenotypes

    • inhibition of pepsinogen release
      • Inhibition of pepsinogen release is caused by SST or by sympathetic stimulation. [4]