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Details for receptor: alpha 1A-adrenoreceptor

EndoNet ID: ENR00799

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  • alpha1A-AR
  • alpha 1A-adrenoreceptor
  • alpha adrenergic receptor 1A
  • alpha1C adrenergic receptor (previous)

General information

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. [1]
  • Binding profiles of antagonists revealed that human prostate predominantly expressed alpha 1A-AR, whereas human aorta expressed alpha 1B-AR mainly. [2]
  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [3]

Links to other resources

UniProt P35348
Ensembl ENST00000380587

Binding hormones

    Anatomical structures with this receptor

    • prostate

    • cerebellar_cortex

    • dentate_nucleus

    • Purkinje_cell

      Induced phenotypes

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 1A ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [3]
    • basket_cell

      Induced phenotypes

      • negative regulation of synaptic transmission, GABAergic
        • Basket cells express abundant alpha 1a AR mRNA. Parallel fibers excitation of basket cell dendrites produces off-beam GABAergic inhibition of Purkinje cells. [3]