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Details for receptor: alpha 1B-adrenoreceptor

EndoNet ID: ENR00800

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  • alpha1B-AR
  • alpha-1B adrenergic receptor
  • alpha 1B-adrenoreceptor

General information

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [1]
  • Binding profiles of antagonists revealed that human prostate predominantly expressed alpha 1A-AR, whereas human aorta expressed alpha 1B-AR mainly. [2]
  • The cerebellar cortex expresses mRNA encoding all six alpha adrenergic receptor subtypes (1a, 1b, 1d, 2a, 2b, 2c), whereas dentate nucleus neurons express all subtype mRNAs, except alpha2a adrenergic receptor mRNA. [3]

Links to other resources

UniProt P35368
Ensembl ENST00000306675

Binding hormones

    Anatomical structures with this receptor

    • aorta

    • cerebellar_cortex

    • dentate_nucleus

    • Purkinje_cell

      Induced phenotypes

      • regulation of inhibitory postsynaptic membrane potential
        • Alpha 1B ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [3]
    • cerebellar_cortex

      Induced phenotypes

      • negative regulation of synaptic transmission, GABAergic
        • Inner stellate cells express moderate levels of alpha 1b AR mRNA. Excitation of stellate cells though parallel fibers produces GABAergic inhibition of Purkinje cells. [3]
        • Ability of the alpha 1b AR subtype tp react faster and to lower levels of norepinephrine may be important in the selective inhibition by stellate cells of specific populations of Purkinje cells. [3]