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Details for receptor: melatonin 1 receptor

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  • General information
  • Subunits
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00816

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • MT1
  • melatonin 1 receptor
  • Mel-1a
  • melatonin 1A
  • MTNR1A
  • Mel1a

General information

Links to other resources

UniProt P48039
Ensembl ENST00000307161

Subunit information

  • evidence on transcript level
Sequence 
MQGNGSALP NASQPVLRG DGARPSWLA 
SALACVLIF TIVVDILGN LLVILSVYR 
NKKLRNAGN IFVVSLAVA DLVVAIYPY 
PLVLMSIFN NGWNLGYLH CQVSGFLMG 
LSVIGSIFN ITGIAINRY CYICHSLKY 
DKLYSSKNS LCYVLLIWL LTLAAVLPN 
LRAGTLQYD PRIYSCTFA QSVSSAYTI 
AVVVFHFLV PMIIVIFCY LRIWILVLQ 
VRQRVKPDR KPKLKPQDF RNFVTMFVV 
FVLFAICWA PLNFIGLAV ASDPASMVP 
RIPEWLFVA SYYMAYFNS CLNAIIYGL 
LNQNFRKEY RRIIVSLCT ARVFFVDSS 
NDVADRVKW KPSPLMTNN NVVKVDSV
UniProt P48039

Binding hormones

  • melatonin

Anatomical structures with this receptor

  • retina

  • hypothalamus

    Influences

    • positive GnRH-I
      • Potential signal transduction mechanisms involved in the control of GnRH gene expression and secretion by melatonin. [1]
    • MSH
    • positive RFRP-1
      • Melatonin stimulates the expression and release of GnIH via melatonin receptors expressed by GnIH neurons. [2]

  • gonads

    Induced phenotypes

    • androgen production
      • Melatonin modulates androgen production at level of gonads. [3]

  • pituitary_gland_of_diencephalon

    Induced phenotypes

    • inhibition of adenylate cyclase activity by G-protein signaling pathway
      • Inhibition of adenylate cyclase at level of pituitary. [4]

  • epiphysis

    Induced phenotypes

    • regulation of circadian rhythm
      • The pineal hormone Melatonin, important role in regulation of circadian rhythm control by interacting with MT1. [5]
    • regulation of seasonal reproduction
      • The pineal hormone Melatonin regulates seasonal rhythms, notably reproduction. [5]
Reference