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Details for receptor: dopamine receptor D2

EndoNet ID: ENR00817

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  • D2
  • dopamine receptor D2
  • DRD-2
  • DRD 2

General information

  • D2 receptors are expressed on the plasma membrane of lactotrophs.
  • Inhibitory, acts through G-poteins; inhibits the activation of adenylate cyclase. [1]
  • Diseases: schizophrenia, Parkinson's disease. [1]
  • D2 was mainly localized in the zona glomerulosa and reticularis of the adrenal cortex and, to a lesser extent, in the zona fasciculata and medulla of normal and hyperplastic adrenal tissue. [2]
  • Couples to multiple effector systems, including the inhibition of adenylate cyclase activity, suppression of Ca(2+) currents, and activation of K(+) currents. [1]
  • Both D2 and D4 receptors were expressed in significant amounts in the adrenal medulla. [3]
  • D2 and D4 receptors were expressed at low levels in the zona fasciculata. [3]

Links to other resources

UniProt P14416
Ensembl ENST00000362072

Binding hormones

  • dopamine

Anatomical structures with this receptor

  • retina

  • lung

  • substantia_nigra

  • tegmentum_of_mesencephalon

  • acidophil_mammotroph_cell_of_anterior_pituitary


    • negative PRL

    Induced phenotypes

    • Hyperprolactinemia
      • Hyperprolactinaemia is common in patients with hypopituitarism, due to the interference of a pituitary mass with dopaminergic inhibition of prolactin secretion. [4]
  • adrenal_gland

  • cell_of_adrenal_gland_zona_glomerulosa


    • negative aldosterone
      • Dopmaine has an inhibitory effect on aldosterone secretion. Type 2 dopamine receptor has been demonstrated in the adrenal glomerulosa. [5]
  • adrenal_medulla

  • cell_of_adrenal_gland_zona_reticularis

  • cell_of_adrenal_gland_zona_fasciculata

  • thalamus

  • cell_of_intermediate_pituitary


    • negative MSH
      • The secretion of melanocyte-stimulating hormone (MSH) by intermediate lobe cells is under the negative influence of the hypothalamus. The predominant role of the tubero-hypophyseal dopaminergic neurons in the inhibitory control of MSH secretion has been demonstrated in mammals. [6]
      • Dopamine (in perifusion model) was responsible for a dose-related inhibition of MSH secretion. [7]
    • The dopamine receptor in the intermediate lobe can be assigned to the category of dopamine receptor designated D-2. [8]
  • corpus_striatum


    • negative acetylcholine
      • Stimulation of D-2 dopamine receptors inhibite therelease of ACh. [9]
  • dentate_gyrus_of_hippocampus