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Details for receptor: M2

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EndoNet ID: ENR00823

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Synonyms

  • muscarinic acetylcholine receptor M2
  • M2
  • CHRM2

General information

  • M2, M4 and M5 muscarinic receptor subtypes bound in human corneal epithelium and endothelium. No binding was found for antibodies to M1 and M3 muscarinic receptor subtypes. [1]

Links to other resources

UniProt P08172
Ensembl ENST00000453373

Subunit information

Sequence 
MNNSTNSSN NSLALTSPY KTFEVVFIV 
LVAGSLSLV TIIGNILVM VSIKVNRHL 
QTVNNYFLF SLACADLII GVFSMNLYT 
LYTVIGYWP LGPVVCDLW LALDYVVSN 
ASVMNLLII SFDRYFCVT KPLTYPVKR 
TTKMAGMMI AAAWVLSFI LWAPAILFW 
QFIVGVRTV EDGECYIQF FSNAAVTFG 
TAIAAFYLP VIIMTVLYW HISRASKSR 
IKKDKKEPV ANQDPVSPS LVQGRIVKP 
NNNNMPSSD DGLEHNKIQ NGKAPRDPV 
TENCVQGEE KESSNDSTS VSAVASNMR 
DDEITQDEN TVSTSLGHS KDENSKQTC 
IRIGTKTPK SDSCTPTNT TVEVVGSSG 
QNGDEKQNI VARKIVKMT KQPAKKKPP 
PSREKKVTR TILAILLAF IITWAPYNV 
MVLINTFCA PCIPNTVWT IGYWLCYIN 
STINPACYA LCNATFKKT FKHLLMCHY 
KNIGATR

Binding hormones

  • acetylcholine

Anatomical structures with this receptor

  • corneal_endothelial_cell

  • corneal_endothelial_cell

  • adrenal_medulla

    Influences

    • positive acetylcholine
      • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [2]
Reference