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Details for receptor: TGF-beta type I receptor

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EndoNet ID: ENR00834

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
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Synonyms

  • TGFbetaR-I
  • TGFR-1
  • TGF-beta type I receptor
  • serine/threonine-protein kinase receptor R4
  • SKR4
  • activin receptor-like kinase 5
  • ALK-5

General information

  • TGF beta type I and II receptors are expressed by endometrial cells and the syncytiotrophoblast of term placenta. [1]
  • Osteoblasts expresses mRNA transcripts of TGF-beta1, TGF-beta2, TGF-beta 3, TGF-beta type I and type II receptors. [2]

Links to other resources

UniProt P36897
Ensembl ENST00000374994

Binding hormones

    Anatomical structures with this receptor

    • isocortex

    • osteoblast

    • cell_of_endometrium_of_uterus

    • placenta

    • propria_mucosa_of_bronchus

      Influences

      • positive PGE2
        • In pulmonary fibroblasts, TGF-beta1 stimulates matrix synthesis while inducing COX expression and PGE2 production. [3]

    • lipocyte_of_liver

    Reference