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Details for receptor: TGF-beta type II receptor

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EndoNet ID: ENR00835

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Synonyms

  • TGFbetaR-II
  • TGFR-2
  • TGF-beta type II receptor

General information

  • TGF-beta1 and its receptor (type II) are expressed in human adrenocortical cells. [1]
  • TGF beta type I and II receptors are expressed by endometrial cells and the syncytiotrophoblast of term placenta. [2]
  • Most normal breast epithelia express high levels of TGF-beta-RII. [3]
  • In women, expression of TGF-b1, -b2 and -b3 and the type II receptor occurs in all cell types of the endometrium. [4]
  • Osteoblasts expresses mRNA transcripts of TGF-beta1, TGF-beta2, TGF-beta 3, TGF-beta type I and type II receptors. [5]

Links to other resources

UniProt P37173
Ensembl ENST00000439925

Subunit information

Sequence 
TIPPHVQKS VNNDMIVTD NNGAVKFPQ 
LCKFCDVRF STCDNQKSC MSNCSITSI 
CEKPQEVCV AVWRKNDEN ITLETVCHD 
PKLPYHDFI LEDAASPKC IMKEKKKPG 
ETFFMCSCS SDECNDNII FSEEYNTSN 
PDLLLVIFQ VTGISLLPP LGVAISVII 
IFYCYRVNR QQKLSSTWE TGKTRKLME 
FSEHCAIIL EDDRSDISS TCANNINHN 
TELLPIELD TLVGKGRFA EVYKAKLKQ 
NTSEQFETV AVKIFPYEE YASWKTEKD 
IFSDINLKH ENILQFLTA EERKTELGK 
QYWLITAFH AKGNLQEYL TRHVISWED 
LRKLGSSLA RGIAHLHSD HTPCGRPKM 
PIVHRDLKS SNILVKNDL TCCLCDFGL 
SLRLDPTLS VDDLANSGQ VGTARYMAP 
EVLESRMNL ENAESFKQT DVYSMALVL 
WEMTSRCNA VGEVKDYEP PFGSKVREH 
PCVESMKDN VLRDRGRPE IPSFWLNHQ 
GIQMVCETL TECWDHDPE ARLTAQCVA 
ERFSELEHL DRLSGRSCS EEKIPEDGS 
LNTTK

Binding hormones

  • TGF-beta 1
  • TGF-beta 2
    • TGF-beta2 has much lower affinity for TbetaRII than TGF-beta1 and -beta3. [6]
  • TGF-beta 3

Anatomical structures with this receptor

  • mammary_gland

  • osteoblast

  • adrenal_cortex

  • cell_of_endometrium_of_uterus

    Influences

    • positive TGF-beta 1
      • TGF-beta 1 has been shown to decrease TGF-beta 2 and TGF-beta 3 expression while enhancing its own expression. [7]
    • positive LIF
      • TGF-beta1 (from 10<sup>–12</sup> to 10<sup>–8</sup>M ), -beta 2 , -beta 3 and activin A (10<sup>–10 and 10</sup>–8 M ) increases LIF secretion by human endometrial epithelium cultures. [8]
    • negative interleukin 6
      • TGF-beta 1(from 10ex–12 to 10ex–8 M ), -beta 2 , -beta 3 and activin A(10ex–10 and 10ex–8 M ) reduces IL-6 release by the human endometrial epithelium. [8]

  • placenta

  • dendritic_cell_in_lymphoid_tissues_follicular

Reference