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Details for receptor: IL-1RI

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EndoNet ID: ENR00861

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Synonyms

  • IL-1R-1
  • IL-1R-alpha
  • IL-1RI
  • p80
  • interleukin-1 receptor, type I
  • antigen CD121a

General information

  • Isolated human osteoclasts(OCs) and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors. [1]
  • IL-1RI was detected in osteoblasts. [1]
  • Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. [2]

Links to other resources

UniProt P14778
Ensembl ENST00000452403

Subunit information

Sequence 
LEADKCKER EEKIILVSS ANEIDVRPC 
PLNPNEHKG TITWYKDDS KTPVSTEQA 
SRIHQHKEK LWFVPAKVE DSGHYYCVV 
RNSSYCLRI KISAKFVEN EPNLCYNAQ 
AIFKQKLPV AGDGGLVCP YMEFFKNEN 
NELPKLQWY KDCKPLLLD NIHFSGVKD 
RLIVMNVAE KHRGNYTCH ASYTYLGKQ 
YPITRVIEF ITLEENKPT RPVIVSPAN 
ETMEVDLGS QIQLICNVT GQLSDIAYW 
KWNGSVIDE DDPVLGEDY YSVENPANK 
RRSTLITVL NISEIESRF YKHPFTCFA 
KNTHGIDAA YIQLIYPVT NFQKHMIGI 
CVTLTVIIV CSVFIYKIF KIDIVLWYR 
DSCYDFLPI KASDGKTYD AYILYPKTV 
GEGSTSDCD IFVFKVLPE VLEKQCGYK 
LFIYGRDDY VGEDIVEVI NENVKKSRR 
LIIILVRET SGFSWLGGS SEEQIAMYN 
ALVQDGIKV VLLELEKIQ DYEKMPESI 
KFIKQKHGA IRWSGDFTQ GPQSAKTRF 
WKNVRYHMP VQRRSPSSK HQLLSPATK 
EKLQREAHV PLG

Binding hormones

  • IL-1 beta
  • IL-1 alpha
  • IL-1RA

Anatomical structures with this receptor

  • osteoblast

  • osteoclast

  • cell_of_endometrium_of_uterus

    Influences

    • positive LIF
      • Treatment with IL-1beta (10 <sup>–9</sup> M ) strongly stimulated LIF and IL-6 production. [3]
    • positive interleukin 6
      • Treatment with IL-1beta (10 <sup>–9</sup> M ) strongly stimulated LIF and IL-6 production. [3]

  • epithelial_cell

  • epithelial_cell_with_microvilli

    Influences

    • positive IL-8
      • IL-1beta and NE (neutrophil elastase) stimulate IL-8 protein production and activate p38 MAPK in bronchial epithelial cells. [4]

  • bronchial_epithelial_cell

    Influences

    • positive IL-8
      • IL-1beta and NE (neutrophil elastase) stimulate IL-8 protein production and activate p38 MAPK in bronchial epithelial cells. [4]
    • positive lipocalin 2

  • pneumocyte_type_II

    Influences

    • positive lipocalin 2
      • IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. [5]
    • positive IL-8

  • parathyroid_gland

    Influences

    • negative PTH
      • IL-1 beta inhibits PTH secretion, this effect is blocked when (equine) parathyroid cells were incubated with an IL-1 receptor antagonist. [6]

  • lipocyte_of_liver

    Influences

    • positive RANTES
      • Hepatic stellate cells secrete RANTES after stimulation with TNF-alpha, IL-1beta, and CD40L in an inhibitor-kappaB (I kappa B)kinase (IKK)2/NF kappaB- and JNK-dependent manner. [7]
Reference