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Details for receptor: PPAR-alpha

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EndoNet ID: ENR00901

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Synonyms

  • peroxisome proliferator-activated receptor alpha
  • PPAR-alpha

General information

  • Many homeostatic responses of the hepatocyte to free fatty acids (FFA) are modulated by PPAR alpha . [1]
  • PPARα is expressed at high levels in organs with significant catabolism of fatty acids. [2]
  • Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. [3]
  • The PPARα is the nuclear receptor for eicosanoids including LTB4 and their interaction promotes degradation of lipid mediators. [4]

Links to other resources

UniProt Q07869
Ensembl ENST00000440343

Subunit information

PPARa

  • Heterodimer with the retinoid X receptor.
Sequence 
MVDTESPLC PLSPLEAGD LESPLSEEF 
LQEMGNIQE ISQSIGEDS SGSFGFTEY 
QYLGSCPGS DGSVITDTL SPASSPSSV 
TYPVVPGSV DESPSGALN IECRICGDK 
ASGYHYGVH ACEGCKGFF RRTIRLKLV 
YDKCDRSCK IQKKNRNKC QYCRFHKCL 
SVGMSHNAI RFGRMPRSE KAKLKAEIL 
TCEHDIEDS ETADLKSLA KRIYEAYLK 
NFNMNKVKA RVILSGKAS NNPPFVIHD 
METLCMAEK TLVAKLVAN GIQNKEAEV 
RIFHCCQCT SVETVTELT EFAKAIPGF 
ANLDLNDQV TLLKYGVYE AIFAMLSSV 
MNKDGMLVA YGNGFITRE FLKSLRKPF 
CDIMEPKFD FAMKFNALE LDDSDISLF 
VAAIICCGD RPGLLNVGH IEKMQEGIV 
HVLRLHLQS NHPDDIFLF PKLLQKMAD 
LRQLVTEHA QLVQIIKKT ESDAALHPL 
LQEIYRDMY

Binding hormones

  • LTB4
    • Leukotriene B4, a potent chemotactic agent that initiates, coordinates, sustains and amplifies the inflammatory response, is shown to be an activating ligand for the transcription factor PPARalpha [5]

Anatomical structures with this receptor

  • adipose_tissue

    • PPARα is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine [2]

  • skeleton_muscle

  • heart

    • PPARα is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine [2]

  • kidney

    • PPARα is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine [2]

  • hepatocyte

    Influences

    • positive APOA5
      • Overexpression of PPAR-alpha enhances the activity of the human ApoA5 gene promoter. [6]
    • positive apo B-100
      • The peroxisome proliferator-activated receptor (PPAR) agonist WY 14,643 increased the secretion of apolipoprotein (apo) B-100, but not that of apoB-48, and decreased triglyceride biosynthesis and secretion from primary rat hepatocytes. These effects resulted in decreased secretion of apoB-100-very low density lipoprotein (VLDL) and an increased secretion of apoB-100 on low density lipoproteins/intermediate density lipoproteins. [7]
    • PPARα is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine [2]

  • digestive_system

    • PPARα is expressed at high levels in organs that carry out significant catabolism of fatty acids such as the brown adipose tissue, liver, heart, kidney, and intestine [2]

  • G_cell

    Influences

    • positive gastrin
      • PPARalpha agonists stimulate progastrin production. [8]

  • beta_cell_of_islet_of_Langerhans

    Influences

    • positive insulin
      • Acute activation of PPAR-alpha, but not PPAR-gamma, has the potential to stimulate mitochondrial ß-oxidation and potentiate glucose-stimulated insulin secretion (GSIS) in both INS-1E insulinoma cells and rat islets. Thus, regulation of PPAR-alpha expression and activity appears essential for adjusting ß-cells to metabolic challenges and for maintenance of ß-cell function. [9]
Reference