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Details for receptor: macrophage-stimulating protein receptor

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EndoNet ID: ENR01022

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Synonyms

  • C-met-related tyrosine kinase
  • CD136 antigen
  • CDw136
  • macrophage stimulating 1 receptor
  • hepatocyte growth factor like protein receptor
  • PTK8 protein tyrosine kinase 8
  • ron tyrosine kinase
  • STK
  • macrophage-stimulating protein receptor
  • MSP receptor
  • p185-Ron
  • MST1R
  • RON

General information

  • Heterodimer formed of an alpha chain and a beta chain which are disulfide linked
  • Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. [1]
  • Receptor for macrophage stimulating protein with tyrosine kinase activity.

Links to other resources

UniProt Q04912
Ensembl ENST00000451369

Subunit information

MSP-receptor alpha chain (1 times)

Sequence 
EDWQCPRTP YAASRDFDV KYVVPSFSA 
GGLVQAMVT YEGDRNESA VFVAIRNRL 
HVLGPDLKS VQSLATGPA GDPGCQTCA 
ACGPGPHGP PGDTDTKVL VLDPALPAL 
VSCGSSLQG RCFLHDLEP QGTAVHLAA 
PACLFSAHH NRPDDCPDC VASPLGTRV 
TVVEQGQAS YFYVASSLD AAVAGSFSP 
RSVSIRRLK ADASGFAPG FVALSVLPK 
HLVSYSIEY VHSFHTGAF VYFLTVQPA 
SVTDDPSAL HTRLARLSA TEPELGDYR 
ELVLDCRFA P
UniProt Q04912

MSP-receptor beta chain (1 times)

Sequence 
GAPEGGQPY PVLQVAHSA PVGAQLATE 
LSIAEGQEV LFGVFVTGK DGGPGVGPN 
SVVCAFPID LLDTLIDEG VERCCESPV 
HPGLRRGLD FFQSPSFCP NPPGLEALS 
PNTSCRHFP LLVSSSFSR VDLFNGLLG 
PVQVTALYV TRLDNVTVA HMGTMDGRI 
LQVELVRSL NYLLYVSNF SLGDSGQPV 
QRDVSRLGD HLLFASGDQ VFQVPIRGP 
GCRHFLTCG RCLRAWHFM GCGWCGNMC 
GQQKECPGS WQQDHCPPK LTEFHPHSG 
PLRGSTRLT LCGSNFYLH PSGLVPEGT 
HQVTVGQSP CRPLPKDSS KLRPVPRKD 
FVEEFECEL EPLGTQAVG PTNVSLTVT 
NMPPGKHFR VDGTSVLRG FSFMEPVLI 
AVQPLFGPR AGGTCLTLE GQSLSVGTS 
RAVLVNGTE CLLARVSEG QLLCATPPG 
ATVASVPLS LQVGGAQVP GSWTFQYRE 
DPVVLSISP NCGYINSHI TICGQHLTS 
AWHLVLSFH DGLRAVESR CERQLPEQQ 
LCRLPEYVV RDPQGWVAG NLSARGDGA 
AGFTLPGFR FLPPPHPPS ANLVPLKPE 
EHAIKFEYI GLGAVADCV GINVTVGGE 
SCQHEFRGD MVVCPLPPS LQLGQDGAP 
LQVCVDGEC HILGRVVRP GPDGVPQST 
LLGILLPLL LLVAALATA LVFSYWWRR 
KQLVLPPNL NDLASLDQT AGATPLPIL 
YSGSDYRSG LALPAIDGL DSTTCVHGA 
SFSDSEDES CVPLLRKES IQLRDLDSA 
LLAEVKDVL IPHERVVTH SDRVIGKGH 
FGVVYHGEY IDQAQNRIQ CAIKSLSRI 
TEMQQVEAF LREGLLMRG LNHPNVLAL 
IGIMLPPEG LPHVLLPYM CHGDLLQFI 
RSPQRNPTV KDLISFGLQ VARGMEYLA 
EQKFVHRDL AARNCMLDE SFTVKVADF 
GLARDILDR EYYSVQQHR HARLPVKWM 
ALESLQTYR FTTKSDVWS FGVLLWELL 
TRGAPPYRH IDPFDLTHF LAQGRRLPQ 
PEYCPDSLY QVMQQCWEA DPAVRPTFR 
VLVGEVEQI VSALLGDHY VQLPATYMN 
LGPSTSHEM NVRPEQPQF SPMPGNVRR 
PRPLSEPPR PT
UniProt Q04912

MSP-receptor

Sequence 
EDWQCPRTP YAASRDFDV KYVVPSFSA 
GGLVQAMVT YEGDRNESA VFVAIRNRL 
HVLGPDLKS VQSLATGPA GDPGCQTCA 
ACGPGPHGP PGDTDTKVL VLDPALPAL 
VSCGSSLQG RCFLHDLEP QGTAVHLAA 
PACLFSAHH NRPDDCPDC VASPLGTRV 
TVVEQGQAS YFYVASSLD AAVAGSFSP 
RSVSIRRLK ADASGFAPG FVALSVLPK 
HLVSYSIEY VHSFHTGAF VYFLTVQPA 
SVTDDPSAL HTRLARLSA TEPELGDYR 
ELVLDCRFA PKRRRRGAP EGGQPYPVL 
QVAHSAPVG AQLATELSI AEGQEVLFG 
VFVTGKDGG PGVGPNSVV CAFPIDLLD 
TLIDEGVER CCESPVHPG LRRGLDFFQ 
SPSFCPNPP GLEALSPNT SCRHFPLLV 
SSSFSRVDL FNGLLGPVQ VTALYVTRL 
DNVTVAHMG TMDGRILQV ELVRSLNYL 
LYVSNFSLG DSGQPVQRD VSRLGDHLL 
FASGDQVFQ VPIRGPGCR HFLTCGRCL 
RAWHFMGCG WCGNMCGQQ KECPGSWQQ 
DHCPPKLTE FHPHSGPLR GSTRLTLCG 
SNFYLHPSG LVPEGTHQV TVGQSPCRP 
LPKDSSKLR PVPRKDFVE EFECELEPL 
GTQAVGPTN VSLTVTNMP PGKHFRVDG 
TSVLRGFSF MEPVLIAVQ PLFGPRAGG 
TCLTLEGQS LSVGTSRAV LVNGTECLL 
ARVSEGQLL CATPPGATV ASVPLSLQV 
GGAQVPGSW TFQYREDPV VLSISPNCG 
YINSHITIC GQHLTSAWH LVLSFHDGL 
RAVESRCER QLPEQQLCR LPEYVVRDP 
QGWVAGNLS ARGDGAAGF TLPGFRFLP 
PPHPPSANL VPLKPEEHA IKFEYIGLG 
AVADCVGIN VTVGGESCQ HEFRGDMVV 
CPLPPSLQL GQDGAPLQV CVDGECHIL 
GRVVRPGPD GVPQSTLLG ILLPLLLLV 
AALATALVF SYWWRRKQL VLPPNLNDL 
ASLDQTAGA TPLPILYSG SDYRSGLAL 
PAIDGLDST TCVHGASFS DSEDESCVP 
LLRKESIQL RDLDSALLA EVKDVLIPH 
ERVVTHSDR VIGKGHFGV VYHGEYIDQ 
AQNRIQCAI KSLSRITEM QQVEAFLRE 
GLLMRGLNH PNVLALIGI MLPPEGLPH 
VLLPYMCHG DLLQFIRSP QRNPTVKDL 
ISFGLQVAR GMEYLAEQK FVHRDLAAR 
NCMLDESFT VKVADFGLA RDILDREYY 
SVQQHRHAR LPVKWMALE SLQTYRFTT 
KSDVWSFGV LLWELLTRG APPYRHIDP 
FDLTHFLAQ GRRLPQPEY CPDSLYQVM 
QQCWEADPA VRPTFRVLV GEVEQIVSA 
LLGDHYVQL PATYMNLGP STSHEMNVR 
PEQPQFSPM PGNVRRPRP LSEPPRPT
UniProt Q04912

Binding hormones

  • MSP
    • RON is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST/MSP ligand. [2]

Anatomical structures with this receptor

  • keratinocyte

    Induced phenotypes

    • wound healing
      • The MSP/RON (receptor for MSP) system promotes wound healing. [3]

  • monocyte

Reference