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Details for receptor: integrin beta-1

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EndoNet ID: ENR01024

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Synonyms

  • integrin beta-1
  • integrin beta 1
  • integrin beta I
  • fibronectin receptor beta subunit
  • integrin VLA-4 beta subunit
  • CD29 antigen
  • ITGB1
  • ITGBI
  • FNRB

General information

  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.
  • Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.
  • Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.
  • Integrin alpha-5/beta-1 is a receptor for fibrinogen.
  • Integrin alpha-1/beta-1 is a single-pass type I membrane receptor for laminin and collagen, heterodimer of an alpha and a beta subunit.
  • 5 isoforms through alternative splicing.
  • Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin.
  • Integrin alpha-4/beta-1 is a receptor for VCAM1.
  • Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.
  • Integrin alpha-V/beta-1 is a receptor for vitronectin.
  • CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. [1]

Links to other resources

UniProt P05556
Ensembl ENST00000437302

Subunit information

Integrin beta 1 isoform 1C-2 mature peptide

Sequence 
QTDENRCLK ANAKSCGEC IQAGPNCGW 
CTNSTFLQE GMPTSARCD DLEALKKKG 
CPPDDIENP RGSKDIKKN KNVTNRSKG 
TAEKLKPED ITQIQPQQL VLRLRSGEP 
QTFTLKFKR AEDYPIDLY YLMDLSYSM 
KDDLENVKS LGTDLMNEM RRITSDFRI 
GFGSFVEKT VMPYISTTP AKLRNPCTS 
EQNCTSPFS YKNVLSLTN KGEVFNELV 
GKQRISGNL DSPEGGFDA IMQVAVCGS 
LIGWRNVTR LLVFSTDAG FHFAGDGKL 
GGIVLPNDG QCHLENNMY TMSHYYDYP 
SIAHLVQKL SENNIQTIF AVTEEFQPV 
YKELKNLIP KSAVGTLSA NSSNVIQLI 
IDAYNSLSS EVILENGKL SEGVTISYK 
SYCKNGVNG TGENGRKCS NISIGDEVQ 
FEISITSNK CPKKDSDSF KIRPLGFTE 
EVEVILQYI CECECQSEG IPESPKCHE 
GNGTFECGA CRCNEGRVG RHCECSTDE 
VNSEDMDAY CRKENSSEI CSNNGECVC 
GQCVCRKRD NTNEIYSGK FCECDNFNC 
DRSNGLICG GNGVCKCRV CECNPNYTG 
SACDCSLDT STCEASNGQ ICNGRGICE 
CGVCKCTDP KFQGQTCEM CQTCLGVCA 
EHKECVQCR AFNKGEKKD TCTQECSYF 
NITKVESRD KLPQPVQPD PVSHCKEKD 
VDDCWFYFT YSVNGNNEV MVHVVENPE 
CPTGPDIIP IVAGVVAGI VLIGLALLL 
IWKLLMIIH DRREFAKFE KEKMNAKWD 
TPGVQWCDI SSLQPLTSR FQQFSCLSL 
PSTWDYRVK ILFIRVP

Integrin beta 1 B

Sequence 
MNLQPIFWI GLISSVCCV FAQTDENRC 
LKANAKSCG ECIQAGPNC GWCTNSTFL 
QEGMPTSAR CDDLEALKK KGCPPDDIE 
NPRGSKDIK KNKNVTNRS KGTAEKLKP 
EDIHQIQPQ QLVLRLRSG EPQTFTLKF 
KRAEDYPID LYYLMDLSY SMKDDLENV 
KSLGTDLMN EMRRITSDF RIGFGSFVE 
KTVMPYIST TPAKLRNPC TSEQNCTTP 
FSYKNVLSL TNKGEVFNE LVGKQRISG 
NLDSPEGGF DAIMQVAVC GSLIGWRNV 
TRLLVFSTD AGFHFAGDG KLGGIVLPN 
DGQCHLENN MYTMSHYYD YPSIAHLVQ 
KLSENNIQT IFAVTEEFQ PVYKELKNL 
IPKSAVGTL SANSSNVIQ LIIDAYNSL 
SSEVILENG KLSEGVTIS YKSYCKNGV 
NGTGENGRK CSNISIGDE VQFEISITS 
NKCPKKDSD SFKIRPLGF TEEVEVILQ 
YICECECQS EGIPESPKC HEGNGTFEC 
GACRCNEGR VGRHCECST DEVNSEDMD 
AYCRKENSS EICSNNGEC VCGQCVCRK 
RDNTNEIYS GKFCECDNF NCDRSNGLI 
CGGNGVCKC RVCECNPNY TGSACDCSL 
DTSTCEASN GQICNGRGI CECGVCKCT 
DPKFQGQTC EMCQTCLGV CAEHKECVQ 
CRAFNKGEK KDTCTQECS YFNITKVES 
RDKLPQPVQ PDPVSHCKE KDVDDCWFY 
FTYSVNGNN EVMVHVVEN PECPTGPDI 
IPIVAGVVA GIVLIGLAL LLIWKLLMI 
IHDRREFAK FEKEKMNAK WDTVSYKTS 
KKQSGL
UniProt P05556-2

Integrin beta 1 C

Sequence 
MNLQPIFWI GLISSVCCV FAQTDENRC 
LKANAKSCG ECIQAGPNC GWCTNSTFL 
QEGMPTSAR CDDLEALKK KGCPPDDIE 
NPRGSKDIK KNKNVTNRS KGTAEKLKP 
EDIHQIQPQ QLVLRLRSG EPQTFTLKF 
KRAEDYPID LYYLMDLSY SMKDDLENV 
KSLGTDLMN EMRRITSDF RIGFGSFVE 
KTVMPYIST TPAKLRNPC TSEQNCTTP 
FSYKNVLSL TNKGEVFNE LVGKQRISG 
NLDSPEGGF DAIMQVAVC GSLIGWRNV 
TRLLVFSTD AGFHFAGDG KLGGIVLPN 
DGQCHLENN MYTMSHYYD YPSIAHLVQ 
KLSENNIQT IFAVTEEFQ PVYKELKNL 
IPKSAVGTL SANSSNVIQ LIIDAYNSL 
SSEVILENG KLSEGVTIS YKSYCKNGV 
NGTGENGRK CSNISIGDE VQFEISITS 
NKCPKKDSD SFKIRPLGF TEEVEVILQ 
YICECECQS EGIPESPKC HEGNGTFEC 
GACRCNEGR VGRHCECST DEVNSEDMD 
AYCRKENSS EICSNNGEC VCGQCVCRK 
RDNTNEIYS GKFCECDNF NCDRSNGLI 
CGGNGVCKC RVCECNPNY TGSACDCSL 
DTSTCEASN GQICNGRGI CECGVCKCT 
DPKFQGQTC EMCQTCLGV CAEHKECVQ 
CRAFNKGEK KDTCTQECS YFNITKVES 
RDKLPQPVQ PDPVSHCKE KDVDDCWFY 
FTYSVNGNN EVMVHVVEN PECPTGPDI 
IPIVAGVVA GIVLIGLAL LLIWKLLMI 
IHDRREFAK FEKEKMNAK WDTSLSVAQ 
PGVQWCDIS SLQPLTSRF QQFSCLSLP 
STWDYRVKI LFIRVP
UniProt P05556-3

Integrin beta 1 C2

Sequence 
MNLQPIFWI GLISSVCCV FAQTDENRC 
LKANAKSCG ECIQAGPNC GWCTNSTFL 
QEGMPTSAR CDDLEALKK KGCPPDDIE 
NPRGSKDIK KNKNVTNRS KGTAEKLKP 
EDIHQIQPQ QLVLRLRSG EPQTFTLKF 
KRAEDYPID LYYLMDLSY SMKDDLENV 
KSLGTDLMN EMRRITSDF RIGFGSFVE 
KTVMPYIST TPAKLRNPC TSEQNCTTP 
FSYKNVLSL TNKGEVFNE LVGKQRISG 
NLDSPEGGF DAIMQVAVC GSLIGWRNV 
TRLLVFSTD AGFHFAGDG KLGGIVLPN 
DGQCHLENN MYTMSHYYD YPSIAHLVQ 
KLSENNIQT IFAVTEEFQ PVYKELKNL 
IPKSAVGTL SANSSNVIQ LIIDAYNSL 
SSEVILENG KLSEGVTIS YKSYCKNGV 
NGTGENGRK CSNISIGDE VQFEISITS 
NKCPKKDSD SFKIRPLGF TEEVEVILQ 
YICECECQS EGIPESPKC HEGNGTFEC 
GACRCNEGR VGRHCECST DEVNSEDMD 
AYCRKENSS EICSNNGEC VCGQCVCRK 
RDNTNEIYS GKFCECDNF NCDRSNGLI 
CGGNGVCKC RVCECNPNY TGSACDCSL 
DTSTCEASN GQICNGRGI CECGVCKCT 
DPKFQGQTC EMCQTCLGV CAEHKECVQ 
CRAFNKGEK KDTCTQECS YFNITKVES 
RDKLPQPVQ PDPVSHCKE KDVDDCWFY 
FTYSVNGNN EVMVHVVEN PECPTGPDI 
IPIVAGVVA GIVLIGLAL LLIWKLLMI 
IHDRREFAK FEKEKMNAK WDTPGVQWC 
DISSLQPLT SRFQQFSCL SLPSTWDYR 
VKILFIRVP
UniProt P05556-4

Integrin beta 1 D

Sequence 
MNLQPIFWI GLISSVCCV FAQTDENRC 
LKANAKSCG ECIQAGPNC GWCTNSTFL 
QEGMPTSAR CDDLEALKK KGCPPDDIE 
NPRGSKDIK KNKNVTNRS KGTAEKLKP 
EDIHQIQPQ QLVLRLRSG EPQTFTLKF 
KRAEDYPID LYYLMDLSY SMKDDLENV 
KSLGTDLMN EMRRITSDF RIGFGSFVE 
KTVMPYIST TPAKLRNPC TSEQNCTTP 
FSYKNVLSL TNKGEVFNE LVGKQRISG 
NLDSPEGGF DAIMQVAVC GSLIGWRNV 
TRLLVFSTD AGFHFAGDG KLGGIVLPN 
DGQCHLENN MYTMSHYYD YPSIAHLVQ 
KLSENNIQT IFAVTEEFQ PVYKELKNL 
IPKSAVGTL SANSSNVIQ LIIDAYNSL 
SSEVILENG KLSEGVTIS YKSYCKNGV 
NGTGENGRK CSNISIGDE VQFEISITS 
NKCPKKDSD SFKIRPLGF TEEVEVILQ 
YICECECQS EGIPESPKC HEGNGTFEC 
GACRCNEGR VGRHCECST DEVNSEDMD 
AYCRKENSS EICSNNGEC VCGQCVCRK 
RDNTNEIYS GKFCECDNF NCDRSNGLI 
CGGNGVCKC RVCECNPNY TGSACDCSL 
DTSTCEASN GQICNGRGI CECGVCKCT 
DPKFQGQTC EMCQTCLGV CAEHKECVQ 
CRAFNKGEK KDTCTQECS YFNITKVES 
RDKLPQPVQ PDPVSHCKE KDVDDCWFY 
FTYSVNGNN EVMVHVVEN PECPTGPDI 
IPIVAGVVA GIVLIGLAL LLIWKLLMI 
IHDRREFAK FEKEKMNAK WDTQENPIY 
KSPINNFKN PNYGRKAGL
UniProt P05556-5

Integrin beta 1 A (1 times)

  • Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. [2]
Sequence 
QTDENRCLK ANAKSCGEC IQAGPNCGW 
CTNSTFLQE GMPTSARCD DLEALKKKG 
CPPDDIENP RGSKDIKKN KNVTNRSKG 
TAEKLKPED IHQIQPQQL VLRLRSGEP 
QTFTLKFKR AEDYPIDLY YLMDLSYSM 
KDDLENVKS LGTDLMNEM RRITSDFRI 
GFGSFVEKT VMPYISTTP AKLRNPCTS 
EQNCTTPFS YKNVLSLTN KGEVFNELV 
GKQRISGNL DSPEGGFDA IMQVAVCGS 
LIGWRNVTR LLVFSTDAG FHFAGDGKL 
GGIVLPNDG QCHLENNMY TMSHYYDYP 
SIAHLVQKL SENNIQTIF AVTEEFQPV 
YKELKNLIP KSAVGTLSA NSSNVIQLI 
IDAYNSLSS EVILENGKL SEGVTISYK 
SYCKNGVNG TGENGRKCS NISIGDEVQ 
FEISITSNK CPKKDSDSF KIRPLGFTE 
EVEVILQYI CECECQSEG IPESPKCHE 
GNGTFECGA CRCNEGRVG RHCECSTDE 
VNSEDMDAY CRKENSSEI CSNNGECVC 
GQCVCRKRD NTNEIYSGK FCECDNFNC 
DRSNGLICG GNGVCKCRV CECNPNYTG 
SACDCSLDT STCEASNGQ ICNGRGICE 
CGVCKCTDP KFQGQTCEM CQTCLGVCA 
EHKECVQCR AFNKGEKKD TCTQECSYF 
NITKVESRD KLPQPVQPD PVSHCKEKD 
VDDCWFYFT YSVNGNNEV MVHVVENPE 
CPTGPDIIP IVAGVVAGI VLIGLALLL 
IWKLLMIIH DRREFAKFE KEKMNAKWD 
TGENPIYKS AVTTVVNPK YEGK
UniProt P05556-1

Binding hormones

  • galectin-3

Anatomical structures with this receptor

  • placenta

  • skeleton_muscle

  • fibroblast

  • propria_mucosa_of_bronchus

Reference