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Details for receptor: frizzled 1

EndoNet ID: ENR01029

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Synonyms

  • Fz1
  • frizzled 1
  • frizzled-1
  • Fz-1
  • hFz1
  • FzE1
  • FZD1
  • frizzled homolog 1 (Drosophila)
  • Wnt receptor

General information

  • Receptor for Wnt proteins. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. [1]
  • Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. [1]

Links to other resources

UniProt Q9UP38
Ensembl ENST00000287934

Subunit information

Sequence
VRAQAAGQG PGQGPGPGQ QPPPPPQQQ 
QSGQQYNGE RGISVPDHG YCQPISIPL 
CTDIAYNQT IMPNLLGHT NQEDAGLEV 
HQFYPLVKV QCSAELKFF LCSMYAPVC 
TVLEQALPP CRSLCERAR QGCEALMNK 
FGFQWPDTL KCEKFPVHG AGELCVGQN 
TSDKGTPTP SLLPEFWTS NPQHGGGGH 
RGGFPGGAG ASERGKFSC PRALKVPSY 
LNYHFLGEK DCGAPCEPT KVYGLMYFG 
PEELRFSRT WIGIWSVLC CASTLFTVL 
TYLVDMRRF SYPERPIIF LSGCYTAVA 
VAYIAGFLL EDRVVCNDK FAEDGARTV 
AQGTKKEGC TILFMMLYF FSMASSIWW 
VILSLTWFL AAGMKWGHE AIEANSQYF 
HLAAWAVPA IKTITILAL GQVDGDVLS 
GVCFVGLNN VDALRGFVL APLFVYLFI 
GTSFLLAGF VSLFRIRTI MKHDGTKTE 
KLEKLMVRI GVFSVLYTV PATIVIACY 
FYEQAFRDQ WERSWVAQS CKSYAIPCP 
HLQAGGGAP PHPPMSPDF TVFMIKYLM 
TLIVGITSG FWIWSGKTL NSWRKFYTR 
LTNSKQGET TV

Binding hormones

  • WNT3A
  • Wnt-3
  • Wnt-1
  • Wnt-2

Anatomical structures with this receptor

  • heart

  • placenta

  • lung

  • kidney

  • pancreas

  • prostate

  • ovary

  • thyroid_gland

  • pancreatic_islets

Reference