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Details for receptor: kremen 2

EndoNet ID: ENR01034

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  • kremen 2
  • kremen protein 2
  • kremen-2
  • kringle domain-containing transmembrane protein 2
  • dickkopf receptor 2
  • KRM2

General information

  • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. [1]
  • Kremen 2 forms a ternary complex with Dkk1 and LRP6, and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. [1]
  • 4 isoforms through alternative splicing.
  • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. [2]

Links to other resources

UniProt Q8NCW0
Ensembl ENST00000451815

Binding hormones

  • Dkk1
  • Dkk4
  • Dkk2

Anatomical structures with this receptor

  • brain

  • uterus