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Details for receptor: TNFRSF13C

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EndoNet ID: ENR01039

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Synonyms

  • TNF receptor superfamily member 13C
  • B cell-activating factor receptor
  • BAFF receptor
  • BAFF-R
  • BLyS receptor 3
  • CD268 antigen
  • BR3
  • TNFRSF13C
  • BAFFR
  • B-cell-activating factor receptor
  • Tumor necrosis factor receptor superfamily member 13C

General information

  • TNFRSF13C is a type III transmembrane protein like BCMA or TACI, but it contains only four cysteine residues in its extracellular ligand binding domain. [1]
  • This makes TNFRSF13C to the smallest Cystein-rich-Domain in the TNF receptorfamily [1]

Links to other resources

UniProt Q96RJ3
Ensembl ENST00000291232

Subunit information

TNF receptor superfamily member 13C, chain

Sequence 
MRRGPRSLR GRDAPAPTP CVPAECFDL 
LVRHCVACG LLRTPRPKP AGASSPAPR 
TALQPQESV GAGAGEAAL PLPGLLFGA 
PALLGLALV LALVLVGLV SWRRRQRRL 
RGASSAEAP DGDKDAPEP LDKVIILSP 
GISDATAPA WPPPGEDPG TTPPGHSVP 
VPATELGST ELVTTKTAG PEQQ
UniProt Q96RJ3

Binding hormones

  • BAFF

Anatomical structures with this receptor

  • spleen

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF13C has a important role in mediating normal immune function. [2]
      • Mice expressing a mutant form of this receptor show severe defects in B-cell development and survival and in T lymphocate-dependent immune respose. [3]
    • Northern blot analysis on human tissues revealed that TNFRSF13C is expressed as a 4.5-kb mRNA in the secondary lymphoid organs. High levels of TNFRSF13C mRNA were detected in the spleen. [1]

  • lymph_node

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF13C has a important role in mediating normal immune function. [2]
      • Mice expressing a mutant form of this receptor show severe defects in B-cell development and survival and in T lymphocate-dependent immune respose. [3]
    • Northern blot analysis on human tissues revealed that TNFRSF13C is expressed as a 4.5-kb mRNA in the secondary lymphoid organs. High levels of TNFRSF13C mRNA were detected in the lymph nodes. [1]

  • B-lymphocyte

    Induced phenotypes

    • negative regulation of B cell apoptosis
      • TNFRSF13C appears to be the principal receptor reqired for BAFF-mediated mature B cell survival and for generating an effective T cell-dependent immune response. [1]
    • TNFRSF13C is a marker of both normal and neoplastic B cells. [2]

  • thymus

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF13C has a important role in mediating normal immune function. [2]
      • Mice expressing a mutant form of this receptor show severe defects in B-cell development and survival and in T lymphocate-dependent immune respose. [3]
    • Northern blot analysis on human tissues revealed that TNFRSF13C is expressed as a 4.5-kb mRNA in the secondary lymphoid organs. Low levels of TNFRSF13C mRNAwere detected in the thymus. [1]
Reference