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Details for receptor: TNFRSF17

EndoNet ID: ENR01040

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  • BCMA
  • CD269 antigen
  • B-cell maturation protein
  • TNF receptor superfamily member 17
  • TNFRSF17
  • BCM
  • Tumor necrosis factor receptor superfamily member 17

General information

  • Promotes B-cell survival and plays a role in the regulation of humoral immunity. [1]
  • BCMA is a Member of the TNF receptor superfamily and is binding, even like TACI, the ligands APRIL and BAFF [2]

Links to other resources

UniProt Q02223
Ensembl ENST00000435355

Binding hormones

  • BAFF

Anatomical structures with this receptor

  • B-lymphocyte

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF17 is a functional member of the TNFR superfamily. It is lacking a "death domain" and its overexpression activates NF-{kappa}B, p38, and JNK. Therefore, upon binding of its corresponding ligand, TNFRSF17 transduces signals for cell survival and proliferation. [3]
    • TNFRSF17 is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes. [4]