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Details for receptor: PLXNB1

EndoNet ID: ENR01047

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  • plexin-B1
  • PLXNB1
  • plexin B1
  • Semaphorin receptor SEP
  • KIAA0407
  • SEP
  • PLXN5
  • plexin 5
  • semaphorin 4D receptor

General information

  • Receptor for SEMA4D. [1]
  • The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. [2]
  • The semaphorin 4D receptor controls invasive growth by coupling with Met. [3]

Links to other resources

UniProt O43157
Ensembl ENST00000456774

Binding hormones

  • SEMA4D
    • The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. [2]
    • Plexin-B1 is the high affinity receptor for CD100/Sema4D. [4]

Anatomical structures with this receptor

  • brain

    Induced phenotypes

    • axon guidance
      • Binding of CD100/Sema4D to plexin-B1 (plexin-B1 associates with active Rac) leads to subsequent RhoA activation, this is responsible for CD100/Sema4D-induced growth cone collapse and neurite retraction, demonstrating a requirement for Rho guanine nuclear exchange factors (RhoGEFs) and RhoA activation in CD100/Sema4D-mediated cytoskeletal changes. [5]
  • kidney

  • fetal brain

    • Semaphorin receptor SEP is expressed at low levels in fetal brain. [1]
  • fetal_kidney

    • Semaphorin receptor SEP is highly expressed in fetal kidney. [1]
  • neuron

  • hippocampus

    Induced phenotypes

    • axon guidance
      • CD100/Sema4D induced growth cone collapse in hippocampal neurons. [6]
      • CD100/Sema4D-Plexin-B1 interactions help to guide developing neuronal cells. [7]
  • retina

  • hepatocyte