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Details for receptor: TXA2-R

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EndoNet ID: ENR01073

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Synonyms

  • TXA2-R
  • thromboxane A2 receptor
  • prostanoid TP receptor
  • TBXA2R
  • TXR

General information

  • TXA2-R activates a phosphatidylinositol-calcium second messenger system.
  • The binding of TXA2 to glomerular thromboxane prostanoid receptors (TP-R) causes intense vasoconstriction in the kidney.
  • The anti-TXA2 receptor labeles vascular smooth muscle cells, vascular endothelial cells, epithelial cells and submucosal glands in the nasal mucosa. [1]
  • The stimulation of TXA2-R by 8-iso-prostaglandin F2alpha is involved in the process of vascular inflammation. [2]

Links to other resources

UniProt P21731
Ensembl ENST00000411851

Subunit information

long isoform

Sequence 
MWPNGSSLG PCFRPTNIT LEERRLIAS 
PWFAASFCV VGLASNLLA LSVLAGARQ 
GGSHTRSSF LTFLCGLVL TDFLGLLVT 
GTIVVSQHA ALFEWHAVD PGCRLCRFM 
GVVMIFFGL SPLLLGAAM ASERYLGIT 
RPFSRPAVA SQRRAWATV GLVWAAALA 
LGLLPLLGV GRYTVQYPG SWCFLTLGA 
ESGDVAFGL LFSMLGGLS VGLSFLLNT 
VSVATLCHV YHGQEAAQQ RPRDSEVEM 
MAQLLGIMV VASVCWLPL LVFIAQTVL 
RNPPAMSPA GQLSRTTEK ELLIYLRVA 
TWNQILDPW VYILFRRAV LRRLQPRLS 
TRPRRVSLC GPAWSTVAR SRLTATSAS 
RVQAILVPQ PPEQLGLQA
UniProt P21731-1

Binding hormones

  • TXA2

Anatomical structures with this receptor

    Reference