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Details for receptor: LXR-beta

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EndoNet ID: ENR01076

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Synonyms

  • liver X receptor beta
  • LXR-beta
  • LXRB
  • oxysterols receptor LXR-beta
  • nuclear orphan receptor LXR-beta
  • ubiquitously-expressed nuclear receptor
  • nuclear receptor NER
  • NR1H2
  • UNR

General information

  • The adrenal gland expresses abundant quantities of both LXR-alpha and LXR-beta as well as the known LXR agonist 22(R)-OH cholesterol, an intermediate in the conversion of cholesterol to pregnenolone. [1]
  • Regulation of hepatic cholesterol homeostasis is mediated by the liver X receptors (LXR-alpha and LXR-beta). [1]
  • Binds naturally occurring oxidized cholesterol derivatives such as 24(S),25-epoxycholesterol, 22(R)-, 24(S)-, and 27-hydroxycholesterol and synthetic nonsteroidal compounds such as T-0901317. [2]

Links to other resources

UniProt P55055
Ensembl ENST00000411902

Subunit information

oxysterols receptor LXR-beta (1 times)

  • Forms a heterodimer with RXR. [3]
Sequence 
MSSPTTSSL DTPLPGNGP PQPGAPSSS 
PTVKEEGPE PWPGGPDPD VPGTDEASS 
ACSTDWVIP DPEEEPERK RKKGPAPKM 
LGHELCRVC GDKASGFHY NVLSCEGCK 
GFFRRSVVR GGARRYACR GGGTCQMDA 
FMRRKCQQC RLRKCKEAG MREQCVLSE 
EQIRKKKIR KQQQQESQS QSQSPVGPQ 
GSSSSASGP GASPGGSEA GSQGSGEGE 
GVQLTAAQE LMIQQLVAA QLQCNKRSF 
SDQPKVTPW PLGADPQSR DARQQRFAH 
FTELAIISV QEIVDFAKQ VPGFLQLGR 
EDQIALLKA STIEIMLLE TARRYNHET 
ECITFLKDF TYSKDDFHR AGLQVEFIN 
PIFEFSRAM RRLGLDDAE YALLIAINI 
FSADRPNVQ EPGRVEALQ QPYVEALLS 
YTRIKRPQD QLRFPRMLM KLVSLRTLS 
SVHSEQVFA LRLQDKKLP PLLSEIWDV 
HE

RXR-alpha (1 times)

Sequence 
MDTKHFLPL DFSTQVNSS LTSPTGRGS 
MAAPSLHPS LGPGIGSPG QLHSPISTL 
SSPINGMGP PFSVISSPM GPHSMSVPT 
TPTLGFSTG SPQLSSPMN PVSSSEDIK 
PPLGLNGVL KVPAHPSGN MASFTKHIC 
AICGDRSSG KHYGVYSCE GCKGFFKRT 
VRKDLTYTC RDNKDCLID KRQRNRCQY 
CRYQKCLAM GMKREAVQE ERQRGKDRN 
ENEVESTSS ANEDMPVER ILEAELAVE 
PKTETYVEA NMGLNPSSP NDPVTNICQ 
AADKQLFTL VEWAKRIPH FSELPLDDQ 
VILLRAGWN ELLIASFSH RSIAVKDGI 
LLATGLHVH RNSAHSAGV GAIFDRVLT 
ELVSKMRDM QMDKTELGC LRAIVLFNP 
DSKGLSNPA EVEALREKV YASLEAYCK 
HKYPEQPGR FAKLLLRLP ALRSIGLKC 
LEHLFFFKL IGDTPIDTF LMEMLEAPH 
QMT
UniProt P19793

Binding hormones

    Anatomical structures with this receptor

    • hepatocyte

      Influences

      • positive cholesterol
        • Liver X receptor (LXR) alpha and beta are the nuclear receptors responsible for regulation of cholesterol metabolism. In physiological conditions, high intracellular cholesterol levels cause increased synthesis of oxysterols, which activate LXR, thus triggering a transcriptional response for cholesterol secretion and catabolism. [4]

    • adrenal_gland

    Reference