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Details for receptor: LXR-alpha

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EndoNet ID: ENR01077

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Synonyms

  • LXR-alpha
  • liver X receptor alpha
  • oxysterols receptor LXR-alpha
  • nuclear orphan receptor LXR-alpha
  • LXRA
  • NR1H3

General information

  • The adrenal gland expresses abundant quantities of both LXR-alpha and LXR-beta as well as the known LXR agonist 22(R)-OH cholesterol, an intermediate in the conversion of cholesterol to pregnenolone. [1]
  • Visceral organs specific expression, strong expression in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. [2]
  • Binds naturally occurring oxidized cholesterol derivatives such as 24(S),25-epoxycholesterol, 22(R)-, 24(S)-, and 27-hydroxycholesterol and synthetic nonsteroidal compounds such as T-0901317. [3]
  • Regulation of hepatic cholesterol homeostasis is mediated by the liver X receptors (LXR-alpha and LXR-beta). [1]

Links to other resources

UniProt Q13133
Ensembl ENST00000457932

Subunit information

oxysterols receptor LXR-alpha (1 times)

  • Heterodimer of LXRA and RXR. [2]
Sequence 
MSLWLGAPV PDIPPDSAV ELWKPGAQD 
ASSQAQGGS SCILREEAR MPHSAGGTA 
GVGLEAAEP TALLTRAEP PSEPTEIRP 
QKRKKGPAP KMLGNELCS VCGDKASGF 
HYNVLSCEG CKGFFRRSV IKGAHYICH 
SGGHCPMDT YMRRKCQEC RLRKCRQAG 
MREECVLSE EQIRLKKLK RQEEEQAHA 
TSLPPRASS PPQILPQLS PEQLGMIEK 
LVAAQQQCN RRSFSDRLR VTPWPMAPD 
PHSREARQQ RFAHFTELA IVSVQEIVD 
FAKQLPGFL QLSREDQIA LLKTSAIEV 
MLLETSRRY NPGSESITF LKDFSYNRE 
DFAKAGLQV EFINPIFEF SRAMNELQL 
NDAEFALLI AISIFSADR PNVQDQLQV 
ERLQHTYVE ALHAYVSIH HPHDRLMFP 
RMLMKLVSL RTLSSVHSE QVFALRLQD 
KKLPPLLSE IWDVHE
UniProt Q13133-1

RXR-alpha (1 times)

Sequence 
MDTKHFLPL DFSTQVNSS LTSPTGRGS 
MAAPSLHPS LGPGIGSPG QLHSPISTL 
SSPINGMGP PFSVISSPM GPHSMSVPT 
TPTLGFSTG SPQLSSPMN PVSSSEDIK 
PPLGLNGVL KVPAHPSGN MASFTKHIC 
AICGDRSSG KHYGVYSCE GCKGFFKRT 
VRKDLTYTC RDNKDCLID KRQRNRCQY 
CRYQKCLAM GMKREAVQE ERQRGKDRN 
ENEVESTSS ANEDMPVER ILEAELAVE 
PKTETYVEA NMGLNPSSP NDPVTNICQ 
AADKQLFTL VEWAKRIPH FSELPLDDQ 
VILLRAGWN ELLIASFSH RSIAVKDGI 
LLATGLHVH RNSAHSAGV GAIFDRVLT 
ELVSKMRDM QMDKTELGC LRAIVLFNP 
DSKGLSNPA EVEALREKV YASLEAYCK 
HKYPEQPGR FAKLLLRLP ALRSIGLKC 
LEHLFFFKL IGDTPIDTF LMEMLEAPH 
QMT
UniProt P19793

Binding hormones

    Anatomical structures with this receptor

    • fat_cell

      Induced phenotypes

      • regulation of gene expression
        • Expression and ligand activation of LXRα has no significant effect on adipogenesis or lipid accumulation and does not modulate the adipogenic activity of PPARγ. The identification of novel LXR adipocyte target genes in cultured cells and in vivo points to an important role for LXR in the regulation of adipocyte gene expression and adipose tissue function distinct from PPARγ. [4]
      • regulation of lipid biosynthetic process
        • LXR activates the coordinate expression of major fatty acid biosynthetic genes (lipogenesis) and increased plasma triglyceride and phospholipid levels. [5]

    • macrophage

    • kidney

    • small_intestine

    • large_intestine

    • adrenal_gland

    • hepatocyte

      Influences

      • negative APOA5
        • Co-transfection of SREBP-1c downregulates APOA5 promoter activity. [6]
      • positive cholesterol
        • Liver X receptor (LXR) alpha and beta are the nuclear receptors responsible for regulation of cholesterol metabolism. In physiological conditions, high intracellular cholesterol levels cause increased synthesis of oxysterols, which activate LXR, thus triggering a transcriptional response for cholesterol secretion and catabolism. [7]

    • lipocyte_of_liver

      Induced phenotypes

      • positive regulation of fatty acid biosynthetic process
        • LXR as a master lipogenic transcription factor, as it directly regulates both sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP) to enhance hepatic fatty acid synthesis. [8]
    Reference