Status
Please wait ...

Details for receptor: CAR

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01079

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • constitutive activator of retinoid response
  • constitutive active response
  • orphan nuclear receptor NR1I3
  • CAR
  • constitutive androstane receptor
  • orphan nuclear receptor MB67

General information

  • Regulation of the CYP 2 family involves nuclear receptors related to the steroid hormone receptor superfamily, such as the constitutive androstane receptor and the retinoic acid receptor. [1]
  • Glucocorticoid agonists, such as dexamethasone, prednisolone or hydrocortisone, specifically increase human car (hCAR) mRNA expression in human hepatocytes. [2]

Links to other resources

UniProt Q14994
Ensembl ENST00000442691

Subunit information

orphan nuclear receptor NR1I3

  • Heterodimer of NR1I3 and RXR.
Sequence 
MASREDELR NCVVCGDQA TGYHFNALT 
CEGCKGFFR RTVSKSIGP TCPFAGSCE 
VSKTQRRHC PACRLQKCL DAGMRKDMI 
LSAEALALR RAKQAQRRA QQTPVQLSK 
EQEELIRTL LGAHTRHMG TMFEQFVQF 
RPPAHLFIH HQPLPTLAP VLPLVTHFA 
DINTFMVLQ VIKFTKDLP VFRSLPIED 
QISLLKGAA VEICHIVLN TTFCLQTQN 
FLCGPLRYT IEDGARVSP TVGFQVEFL 
ELLFHFHGT LRKLQLQEP EYVLLAAMA 
LFSPDRPGV TQRDEIDQL QEEMALTLQ 
SYIKGQQRR PRDRFLYAK LLGLLAELR 
SINEAYGYQ IQHIQGLSA MMPLLQEIC 
S
UniProt Q14994-1

Binding hormones

    Anatomical structures with this receptor

    • hepatocyte

    Reference