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Details for receptor: MUSK

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EndoNet ID: ENR01100

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Synonyms

  • MUSK
  • muscle skeletal receptor tyrosine kinase
  • muscle-specific kinase receptor

General information

  • Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. [1]
  • Interacts with LRP4; the heterodimer forms an AGRIN receptor complex that binds AGRIN resulting in activation of MUSK. [1]

Links to other resources

UniProt O15146
Ensembl ENST00000416899

Binding hormones

    Anatomical structures with this receptor

    • skeleton_muscle

      Induced phenotypes

      • formation of neuromuscular junction
        • MuSK is a receptor tyrosine kinase essential for neuromuscular junction formation. [2]
      • As indicated by its name, MuSK is a muscle-specific receptor tyrosine kinase that does not express in other tissues in mammals. [2]
    Reference