Status
Please wait ...

Details for receptor: NPR1

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01108

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • NPR1
  • natriuretic peptide receptor A
  • atrial natriuretic peptide receptor A
  • ANP-A
  • ANPRA
  • NPR-A
  • GC-A
  • guanylate cyclase
  • GUC2A

General information

  • Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP).

Links to other resources

UniProt P16066
Ensembl ENST00000428723

Subunit information

Sequence 
GNLTVAVVL PLANTSYPW SWARVGPAV 
ELALAQVKA RPDLLPGWT VRTVLGSSE 
NALGVCSDT AAPLAAVDL KWEHNPAVF 
LGPGCVYAA APVGRFTAH WRVPLLTAG 
APALGFGVK DEYALTTRA GPSYAKLGD 
FVAALHRRL GWERQALML YAYRPGDEE 
HCFFLVEGL FMRVRDRLN ITVDHLEFA 
EDDLSHYTR LLRTMPRKG RVIYICSSP 
DAFRTLMLL ALEAGLCGE DYVFFHLDI 
FGQSLQGGQ GPAPRRPWE RGDGQDVSA 
RQAFQAAKI ITYKDPDNP EYLEFLKQL 
KHLAYEQFN FTMEDGLVN TIPASFHDG 
LLLYIQAVT ETLAHGGTV TDGENITQR 
MWNRSFQGV TGYLKIDSS GDRETDFSL 
WDMDPENGA FRVVLNYNG TSQELVAVS 
GRKLNWPLG YPPPDIPKC GFDNEDPAC 
NQDHLSTLE VLALVGSLS LLGILIVSF 
FIYRKMQLE KELASELWR VRWEDVEPS 
SLERHLRSA GSRLTLSGR GSNYGSLLT 
TEGQFQVFA KTAYYKGNL VAVKRVNRK 
RIELTRKVL FELKHMRDV QNEHLTRFV 
GACTDPPNI CILTEYCPR GSLQDILEN 
ESITLDWMF RYSLTNDIV KGMLFLHNG 
AICSHGNLK SSNCVVDGR FVLKITDYG 
LESFRDLDP EQGHTVYAK KLWTAPELL 
RMASPPVRG SQAGDVYSF GIILQEIAL 
RSGVFHVEG LDLSPKEII ERVTRGEQP 
PFRPSLALQ SHLEELGLL MQRCWAEDP 
QERPPFQQI RLTLRKFNR ENSSNILDN 
LLSRMEQYA NNLEELVEE RTQAYLEEK 
RKAEALLYQ ILPHSVAEQ LKRGETVQA 
EAFDSVTIY FSDIVGFTA LSAESTPMQ 
VVTLLNDLY TCFDAVIDN FDVYKVETI 
GDAYMVVSG LPVRNGRLH ACEVARMAL 
ALLDAVRSF RIRHRPQEQ LRLRIGIHT 
GPVCAGVVG LKMPRYCLF GDTVNTASR 
MESNGEALK IHLSSETKA VLEEFGGFE 
LELRGDVEM KGKGKVRTY WLLGERGSS 
TRG

Binding hormones

  • BNP-32
  • atrial natriuretic factor

Anatomical structures with this receptor

  • adrenal_cortex

    Influences

    • negative aldosterone
      • In humans and experimental animals, administration of atrial natriuretic peptide (ANP) decreases plasma aldosterone levels by direct inhibition of steroid biosynthesis at the adrenal level. [1]
      • ANP-dependent decreases in aldosterone secretion from the adrenal gland require reductions in cAMP concentrations. [2]
      • ANP-dependent activation of NPR-A produces cGMP and stimulates cAMP-hydrolyzing PDE2. [2]

  • kidney

    Influences

    • negative renin
      • In humans and experimental animals, administration of atrial natriuretic peptide (ANP) decreases plasma aldosterone levels by inhibiting renin secretion. [1]
      • ANP decreases renin secretion from the juxtaglomerular cells via a PKGII-dependent process (NPR1-involved). [2]

    Induced phenotypes

    • natriuresis
      • ANP-dependent diuresis and natriuresis are mediated exclusively by NPR-A in mice because these effects are completely lost in NPR-A knockout animals. [2]
    • diuresis
      • ANP-dependent diuresis and natriuresis are mediated exclusively by NPR-A in mice because these effects are completely lost in NPR-A knockout animals. [2]
    • Human and rat NPR-A mRNA are highly expressed in kidney. [2]

  • smooth_muscle_cell

    Induced phenotypes

    • vascular relaxation
      • The ability of the cardiac natriuretic peptides to relax precontracted aortic rings requires NPR-A. [2]
      • ANP stimulation of NPR-A increases intracellular cGMP concentrations which leads after several steps to vascular smooth muscle relaxation. [2]
    • In cultured cells, NPR-A is readily found in primary vascular smooth muscle cells. [2]

  • lung

    Induced phenotypes

    • dilation of pulmonary airways
      • All three natriuretic peptide receptors are highly expressed in the lung. ANP stimulates the dilation of pulmonary airways and blood vessels via NPR-A. [2]
    • All three natriuretic peptide receptors are highly expressed in the lung. [2]
Reference