Status
Please wait ...

Details for receptor: B-cell receptor CD22

EndoNet ID: ENR01117

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • B-cell receptor CD22
  • sialic acid-binding Ig-like lectin 2
  • Siglec-2
  • Leu-14
  • B-lymphocyte cell adhesion molecule
  • BL-CAM

General information

  • Binds sialylated glycoproteins. [1]
  • CD22 is an inhibitory co-receptor of B cell receptor (BCR)-mediated signalling which binds specifically to glycan ligands containing alpha2,6-linked sialic acids. [2]

Links to other resources

UniProt P20273
Ensembl ENST00000419549

Subunit information

CD22-beta

Sequence
DSSKWVFEH PETLYAWEG ACVWIPCTY 
RALDGDLES FILFHNPEY NKNTSKFDG 
TRLYESTKD GKVPSEQKR VQFLGDKNK 
NCTLSIHPV HLNDSGQLG LRMESKTEK 
WMERIHLNV SERPFPPHI QLPPEIQES 
QEVTLTCLL NFSCYGYPI QLQWLLEGV 
PMRQAAVTS TSLTIKSVF TRSELKFSP 
QWSHHGKIV TCQLQDADG KFLSNDTVQ 
LNVKHTPKL EIKVTPSDA IVREGDSVT 
MTCEVSSSN PEYTTVSWL KDGTSLKKQ 
NTFTLNLRE VTKDQSGKY CCQVSNDVG 
PGRSEEVFL QVQYAPEPS TVQILHSPA 
VEGSQVEFL CMSLANPLP TNYTWYHNG 
KEMQGRTEE KVHIPKILP WHAGTYSCV 
AENILGTGQ RGPGAELDV QYPPKKVTT 
VIQNPMPIR EGDTVTLSC NYNSSNPSV 
TRYEWKPHG AWEEPSLGV LKIQNVGWD 
NTTIACAAC NSWCSWASP VALNVQYAP 
RDVRVRKIK PLSEIHSGN SVSLQCDFS 
SSHPKEVQF FWEKNGRLL GKESQLNFD 
SISPEDAGS YSCWVNNSI GQTASKAWT 
LEVLYAPRR LRVSMSPGD QVMEGKSAT 
LTCESDANP PVSHYTWFD WNNQSLPYH 
SQKLRLEPV KVQHSGAYW CQGTNSVGK 
GRSPLSTLT VYYSPETIG RRVAVGLGS 
CLAILILAI CGLKLQRRW KRTQSQQGL 
QENSSGQSF FVRNKKVRR APLSEGPHS 
LGCYNPMME DGISYTTLR FPEMNIPRT 
GDAESSEMQ RPPPDCDDT VTYSALHKR 
QVGDYENVI PDFPEDEGI HYSELIQFG 
VGERPQAQE NVDYVILKH
UniProt P20273-1

Binding hormones

    Anatomical structures with this receptor

    • B-lymphocyte

    Reference