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Details for receptor: integrin alphaV/beta3

EndoNet ID: ENR01152

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  • integrin alphaV/beta3
  • integrin alpha-V/beta-3
  • integrin alphaV-beta3

General information

Links to other resources

Binding hormones

  • tumstatin
  • osteopontin
  • vitronectin
    • Vitronectin can bind to both integrins αvβ3 and αvβ5 [1]
  • CYR61
    • In endothelial cells CYR61binds ITGAV/ITGB3 [2]
  • CTGF
    • CTGF has been shown to interact with the vitronectin receptor, integrin αvβ3. [3]
  • NOV
    • Endothelial cells adhere to NOV protein via a mechanism that involves both αvβ3 and α5β1. [3]
  • osteomodulin
    • Osteomodulin has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. [2]

Anatomical structures with this receptor

  • endothelial_cell

    Induced phenotypes

    • endothelial cell adhesion
      • In this study, we show that purified CTGF protein promotes the adhesion of microvascular endothelial cells through the integrin receptor αvβ3. [1]
    • positive regulation of endothelial cell migration
      • CTGF stimulates the migration of microvascular endothelial cells in culture, also through an integrin-αvβ3-dependent mechanism. [1]
    • The angiogenic integrins, αvβ3 and αvβ5, which are expressed on endothelial cells, are crucial for their survival [4]