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Details for receptor: CEACAM-6

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EndoNet ID: ENR01157

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Synonyms

  • CEACAM-6
  • NCA
  • CEACAM6
  • CD66c
  • carcinoembryonic antigen related CAM 6
  • carcinoembryonic antigen related cell adhesion molecule 6
  • carcinoembryonic antigen-like
  • CEAL
  • non-specific cross reacting antigen
  • normal cross-reacting antigen 50_90
  • CEAM6

General information

  • Overexpression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6, a feature of this malignancy, is associated with resistance to anoikis and increased metastasis. [1]
  • Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. [2]
  • CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. [3]
  • A distinct subset of regulatory CD8+ T cells is activated by nonspecific cross-reacting antigen (CEACAM6) on placental trophoblasts. [4]

Links to other resources

UniProt P40199
Ensembl ENST00000412062

Subunit information

CEACAM6

Sequence 
KLTIESTPF NVAEGKEVL LLAHNLPQN 
RIGYSWYKG ERVDGNSLI VGYVIGTQQ 
ATPGPAYSG RETIYPNAS LLIQNVTQN 
DTGFYTLQV IKSDLVNEE ATGQFHVYP 
ELPKPSISS NNSNPVEDK DAVAFTCEP 
EVQNTTYLW WVNGQSLPV SPRLQLSNG 
NMTLTLLSV KRNDAGSYE CEIQNPASA 
NRSDPVTLN VLYGPDVPT ISPSKANYR 
PGENLNLSC HAASNPPAQ YSWFINGTF 
QQSTQELFI PNITVNNSG SYMCQAHNS 
ATGLNRTTV TMITVSG
UniProt P40199

Binding hormones

    Anatomical structures with this receptor

    • neutrophil_granulocyte

    Reference