Status
Please wait ...

Details for receptor: leukosialin

  • Top
  • General information
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01161

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • leukosialin
  • leukocyte sialoglycoprotein
  • sialophorin
  • galactoglycoprotein
  • GALGP
  • CD43 antigen
  • SPN
  • gpL115

General information

  • CD43 is shed in vivo during neutrophil migration to the inflammatory site. [1]
  • May have a role in cancer development.
  • Cell surface-associated mucin that is abundantly expressed by most leukocytes, and that appears to function as a negative regulator of cell surface interactions. [2]
  • Leukosialin (CD43) is proteolytically cleaved from stimulated HMC-1 cells. [3]
  • CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). [4]
  • Leukosialin expression is differentially regulated by retinoic acids. Vitamin A metabolites could act directly on the CD43 gene, since putative retinoic acid response elements have been detected within its regulatory regions. [5]
  • Acts in T cell activation, neutrophil migration, immunity and tumor mesothelial cell adhesion. [6]
  • Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. [7]
  • CD43 and CD7 may act as a complex during the delivery of galectin-1 apoptotic signals. [8]
  • Altered glycosylation of CD43 and CD45 has been observed in HIV-1 infection of T-cells. This results in accumulation of exposed lactosamine residues, oligosaccharides recognized by galectin-1 on CD43 and CD45, promoting galectin-1 binding, receptor cross-linking, and segregation, critical steps in triggering apoptosis. [8]

Links to other resources

UniProt P16150
Ensembl ENST00000436527

Binding hormones

    Anatomical structures with this receptor

    • thymocyte

    • T-lymphocyte

    • neutrophil_granulocyte

    Reference