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Details for receptor: nephrin

EndoNet ID: ENR01207

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Synonyms

  • nephrin
  • renal glomerulus-specific cell adhesion receptor
  • NPHS1

General information

  • Defects in the gene NPHS1 in chromosome 19 cause the massive proteinuria of Finnish type congenital nephrotic syndrome (CNF). [1]

Links to other resources

UniProt O60500
Ensembl ENST00000443172

Subunit information

isoform 1

  • Single-pass type I membrane protein. [2]
Sequence
QLAIPASVP RGFWALPEN LTVVEGASV 
ELRCGVSTP GSAVQWAKD GLLLGPDPR 
IPGFPRYRL EGDPARGEF HLHIEACDL 
SDDAEYECQ VGRSEMGPE LVSPRVILS 
ILVPPKLLL LTPEAGTMV TWVAGQEYV 
VNCVSGDAK PAPDITILL SGQTISDIS 
ANVNEGSQQ KLFTVEATA RVTPRSSDN 
RQLLVCEAS SPALEAPIK ASFTVNVLF 
PPGPPVIEW PGLDEGHVR AGQSLELPC 
VARGGNPLA TLQWLKNGQ PVSTAWGTE 
HTQAVARSV LVMTVRPED HGAQLSCEA 
HNSVSAGTQ EHGITLQVT FPPSAIIIL 
GSASQTENK NVTLSCVSK SSRPRVLLR 
WWLGWRQLL PMEETVMDG LHGGHISMS 
NLTFLARRE DNGLTLTCE AFSEAFTKE 
TFKKSLILN VKYPAQKLW IEGPPEGQK 
LRAGTRVRL VCLAIGGNP EPSLMWYKD 
SRTVTESRL PQESRRVHL GSVEKSGST 
FSRELVLVT GPSDNQAKF TCKAGQLSA 
STQLAVQFP PTNVTILAN ASALRPGDA 
LNLTCVSVS SNPPVNLSW DKEGERLEG 
VAAPPRRAP FKGSAAARS VLLQVSSRD 
HGQRVTCRA HSAELRETV SSFYRLNVL 
YRPEFLGEQ VLVVTAVEQ GEALLPVSV 
SANPAPEAF NWTFRGYRL SPAGGPRHR 
ILSSGALHL WNVTRADDG LYQLHCQNS 
EGTAEARLR LDVHYAPTI RALQDPTEV 
NVGGSVDIV CTVDANPIL PGMFNWERL 
GEDEEDQSL DDMEKISRG PTGRLRIHH 
AKLAQAGAY QCIVDNGVA PPARRLLRL 
VVRFAPQVE HPTPLTKVA AAGDSTSSA 
TLHCRARGV PNIVFTWTK NGVPLDLQD 
PRYTEHTYH QGGVHSSLL TIANVSAAQ 
DYALFTCTA TNALGSDQT NIQLVSISR 
PDPPSGLKV VSLTPHSVG LEWKPGFDG 
GLPQRFCIR YEALGTPGF HYVDVVPPQ 
ATTFTLTGL QPSTRYRVW LLASNALGD 
SGLADKGTQ LPITTPGLH QPSGEPEDQ 
LPTEPPSGP SGLPLLPVL FALGGLLLL 
SNASCVGGV LWQRRLRRL AEGISEKTE 
AGSEEDRVR NEYEESQWT GERDTQSST 
VSTTEAEPY YRSLRDFSP QLPPTQEEV 
SYSRGFTGE DEDMAFPGH LYDEVERTY 
PPSGAWGPL YDEVQMGPW DLHWPEDTY 
QDPRGIYDQ VAGDLDTLE PDSLPFELR 
GHLV
UniProt O60500-1

Binding hormones

    Anatomical structures with this receptor

    • podocyte

    Reference