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Details for receptor: vasorin

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EndoNet ID: ENR01211

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Synonyms

  • vasorin
  • slit-like 2
  • VASN
  • SLITL2
  • MRX85
  • mental retardation, X-linked 85

General information

  • Vasorin is a typical type I membrane protein, containing tandem arrays of a characteristic leucine-rich repeat motif, an epidermal growth factor-like motif, and a fibronectin type III-like motif at the extracellular domain. [1]
  • Interacts with TGFB1, TGFB2 and TGFB3. [2]
  • Vasorin is a cell-surface glycoprotein which is also expressed as soluble vasorin. [1]
  • Vasorin is a transforming growth factor β-binding protein expressed in vascular smooth muscle cells, and modulates the arterial response to injury in vivo. [1]

Links to other resources

UniProt Q6EMK4
Ensembl ENST00000304735

Subunit information

vasorin

Sequence 
CPSGCQCSQ PQTVFCTAR QGTTVPRDV 
PPDTVGLYV FENGITMLD AGSFAGLPG 
LQLLDLSQN QIASLPSGV FQPLANLSN 
LDLTANRLH EITNETFRG LRRLERLYL 
GKNRIRHIQ PGAFDTLDR LLELKLQDN 
ELRALPPLR LPRLLLLDL SHNSLLALE 
PGILDTANV EALRLAGLG LQQLDEGLF 
SRLRNLHDL DVSDNQLER VPPVIRGLR 
GLTRLRLAG NTRIAQLRP EDLAGLAAL 
QELDVSNLS LQALPGDLS GLFPRLRLL 
AAARNPFNC VCPLSWFGP WVRESHVTL 
ASPEETRCH FPPKNAGRL LLELDYADF 
GCPATTTTA TVPTTRPVV REPTALSSS 
LAPTWLSPT EPATEAPSP PSTAPPTVG 
PVPQPQDCP PSTCLNGGT CHLGTRHHL 
ACLCPEGFT GLYCESQMG QGTRPSPTP 
VTPRPPRSL TLGIEPVSP TSLRVGLQR 
YLQGSSVQL RSLRLTYRN LSGPDKRLV 
TLRLPASLA EYTVTQLRP NATYSVCVM 
PLGPGRVPE GEEACGEAH TPPAVHSNH 
APVTQAREG NLPLLIAPA LAAVLLAAL 
AAVGAAYCV RRGRAMAAA AQDKGQVGP 
GAGPLELEG VKVPLEPGP KATEGGGEA 
LPSGSECEV PLMGFPGPG LQSPLHAKP 
YI
UniProt Q6EMK4

Binding hormones

  • TGF-beta 1
  • TGF-beta 2
  • TGF-beta 3

Anatomical structures with this receptor

  • aorta

  • kidney

  • placenta

  • brain

  • heart

  • lung

  • skeleton_muscle

  • smooth_muscle_cell

    Influences

    • negative TGF-beta 1
      • We found that vasorin directly binds to transforming growth factor (TGF)-β and attenuates TGF-β signaling in vitro. [1]

    Induced phenotypes

    • negative regulation of transforming growth factor beta receptor signaling pathway
      • Vasorin is predominantly expressed in VSMCs and modulates the vascular response to injury, at least in part, by attenuating TGF-β signaling in vivo. [1]
    • Vasorinis predominantly expressed by vascular smooth muscle cells. [1]

  • umbilical_vein_endothelial_cells

  • umbilical_vein

  • umbilical_cord

Reference