Status
Please wait ...

Details for receptor: glypican 1

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01212

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • glypican 1
  • GPC1
  • glypican proteoglycan 1
  • glypican-1
  • glypican1

General information

  • Interacts with APP (amyloid beta A4 precursor protein). [1]
  • Glypican1 is a cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the TGF-beta family. [2]
  • GPC1 plays a role in pancreatic cancer by regulating growth factor responsiveness. [2]
  • Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. [3]
  • Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165. [4]

Links to other resources

UniProt P35052
Ensembl ENST00000455111

Subunit information

Glypican-1.

Sequence 
DPASKSRSC GEVRQIYGA KGFSLSDVP 
QAEISGEHL RICPQGYTC CTSEMEENL 
ANRSHAELE TALRDSSRV LQAMLATQL 
RSFDDHFQH LLNDSERTL QATFPGAFG 
ELYTQNARA FRDLYSELR LYYRGANLH 
LEETLAEFW ARLLERLFK QLHPQLLLP 
DDYLDCLGK QAEALRPFG EAPRELRLR 
ATRAFVAAR SFVQGLGVA SDVVRKVAQ 
VPLGPECSR AVMKLVYCA HCLGVPGAR 
PCPDYCRNV LKGCLANQA DLDAEWRNL 
LDSMVLITD KFWGTSGVE SVIGSVHTW 
LAEAINALQ DNRDTLTAK VIQGCGNPK 
VNPQGPGPE EKRRRGKLA PRERPPSGT 
LEKLVSEAK AQLRDVQDF WISLPGTLC 
SEKMALSTA SDDRCWNGM ARGRYLPEV 
MGDGLANQI NNPEVEVDI TKPDMTIRQ 
QIMQLKIMT NRLRSAYNG NDVDFQDAS 
DDGSGSGSG DGCLDDLCG RKVSRKSSS 
SRTPLTHAL PGLSEQEGQ KTS
UniProt P35052

Binding hormones

  • slit-2 isoform 1 C-product
  • slit-2 isoform 1 N-product
  • cripto-1
  • VEGF-165

Anatomical structures with this receptor

  • bone_marrow

  • propria_mucosa_of_bronchus

  • breast

  • mammary_gland

  • ovary

  • skeleton_muscle

  • brain

    • Glypican 1 is localized in special membrane domains called detergent-insoluble, glycoshingolipid-enriched (DIG) domains. [5]
Reference