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Details for receptor: Integrin alpha-3

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  • General information
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR01318

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Synonyms

  • FRP-2
  • CD49 antigen-like family member C
  • GAPB3
  • VLA-3 subunit alpha
  • Integrin alpha-3
  • Galactoprotein B3
  • CD49c

General information

  • Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. [1]

Links to other resources

UniProt P26006
Ensembl ENST00000320031

Subunit information

Isoform Alpha-3B

  • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. [1]
Sequence 
MGPGPSRAP RAPRLMLCA LALMVAAGG 
CVVSAFNLD TRFLVVKEA GNPGSLFGY 
SVALHRQTE RQQRYLLLA GAPRELAVP 
DGYTNRTGA VYLCPLTAH KDDCERMNI 
TVKNDPGHH IIEDMWLGV TVASQGPAG 
RVLVCAHRY TQVLWSGSE DQRRMVGKC 
YVRGNDLEL DSSDDWQTY HNEMCNSNT 
DYLETGMCQ LGTSGGFTQ NTVYFGAPG 
AYNWKGNSY MIQRKEWDL SEYSYKDPE 
DQGNLYIGY TMQVGSFIL HPKNITIVT 
GAPRHRHMG AVFLLSQEA GGDLRRRQV 
LEGSQVGAY FGSAIALAD LNNDGWQDL 
LVGAPYYFE RKEEVGGAI YVFMNQAGT 
SFPAHPSLL LHGPSGSAF GLSVASIGD 
INQDGFQDI AVGAPFEGL GKVYIYHSS 
SKGLLRQPQ QVIHGEKLG LPGLATFGY 
SLSGQMDVD ENFYPDLLV GSLSDHIVL 
LRARPVINI VHKTLVPRP AVLDPALCT 
ATSCVQVEL CFAYNQSAG NPNYRRNIT 
LAYTLEADR DRRPPRLRF AGSESAVFH 
GFFSMPEMR CQKLELLLM DNLRDKLRP 
IIISMNYSL PLRMPDRPR LGLRSLDAY 
PILNQAQAL ENHTEVQFQ KECGPDNKC 
ESNLQMRAA FVSEQQQKL SRLQYSRDV 
RKLLLSINV TNTRTSERS GEDAHEALL 
TLVVPPALL LSSVRPPGA CQANETIFC 
ELGNPFKRN QRMELLIAF EVIGVTLHT 
RDLQVQLQL STSSHQDNL WPMILTLLV 
DYTLQTSLS MVNHRLQSF FGGTVMGES 
GMKTVEDVG SPLKYEFQV GPMGEGLVG 
LGTLVLGLE WPYEVSNGK WLLYPTEIT 
VHGNGSWPC RPPGDLINP LNLTLSDPG 
DRPSSPQRR RRQLDPGGG QGPPPVTLA 
AAKKAKSET VLTCATGRA HCVWLECPI 
PDAPVVTNV TVKARVWNS TFIEDYRDF 
DRVRVNGWA TLFLRTSIP TINMENKTT 
WFSVDIDSE LVEELPAEI ELWLVLVAV 
GAGLLLLGL IILLLWKCD FFKRTRYYQ 
IMPKYHAVR IREEERYPP PGSTLPTKK 
HWVTSWQTR DQYY
UniProt P26006-1

Isoform Alpha-3A

  • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. [1]
Sequence 
MGPGPSRAP RAPRLMLCA LALMVAAGG 
CVVSAFNLD TRFLVVKEA GNPGSLFGY 
SVALHRQTE RQQRYLLLA GAPRELAVP 
DGYTNRTGA VYLCPLTAH KDDCERMNI 
TVKNDPGHH IIEDMWLGV TVASQGPAG 
RVLVCAHRY TQVLWSGSE DQRRMVGKC 
YVRGNDLEL DSSDDWQTY HNEMCNSNT 
DYLETGMCQ LGTSGGFTQ NTVYFGAPG 
AYNWKGNSY MIQRKEWDL SEYSYKDPE 
DQGNLYIGY TMQVGSFIL HPKNITIVT 
GAPRHRHMG AVFLLSQEA GGDLRRRQV 
LEGSQVGAY FGSAIALAD LNNDGWQDL 
LVGAPYYFE RKEEVGGAI YVFMNQAGT 
SFPAHPSLL LHGPSGSAF GLSVASIGD 
INQDGFQDI AVGAPFEGL GKVYIYHSS 
SKGLLRQPQ QVIHGEKLG LPGLATFGY 
SLSGQMDVD ENFYPDLLV GSLSDHIVL 
LRARPVINI VHKTLVPRP AVLDPALCT 
ATSCVQVEL CFAYNQSAG NPNYRRNIT 
LAYTLEADR DRRPPRLRF AGSESAVFH 
GFFSMPEMR CQKLELLLM DNLRDKLRP 
IIISMNYSL PLRMPDRPR LGLRSLDAY 
PILNQAQAL ENHTEVQFQ KECGPDNKC 
ESNLQMRAA FVSEQQQKL SRLQYSRDV 
RKLLLSINV TNTRTSERS GEDAHEALL 
TLVVPPALL LSSVRPPGA CQANETIFC 
ELGNPFKRN QRMELLIAF EVIGVTLHT 
RDLQVQLQL STSSHQDNL WPMILTLLV 
DYTLQTSLS MVNHRLQSF FGGTVMGES 
GMKTVEDVG SPLKYEFQV GPMGEGLVG 
LGTLVLGLE WPYEVSNGK WLLYPTEIT 
VHGNGSWPC RPPGDLINP LNLTLSDPG 
DRPSSPQRR RRQLDPGGG QGPPPVTLA 
AAKKAKSET VLTCATGRA HCVWLECPI 
PDAPVVTNV TVKARVWNS TFIEDYRDF 
DRVRVNGWA TLFLRTSIP TINMENKTT 
WFSVDIDSE LVEELPAEI ELWLVLVAV 
GAGLLLLGL IILLLWKCG FFKRARTRA 
LYEAKRQKA EMKSQPSET ERLTDDY
UniProt P26006-2

Binding hormones

  • laminin alpha-5 chain

Anatomical structures with this receptor

  • smooth_muscle_cell

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Induced phenotypes

    • glomerulogenesis
      • Together, podocytes and endothelial cells synthesize the glomerular basement membrane (GBM) and assemble the tri-layered glomerular filtration barrier. Major GBM components, such as laminin alpha5, form a structural framework for glomerular development, and both laminin alpha5 and its receptor alpha3 integrin are required for glomerulogenesis. [2]
Reference