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Details for receptor: Sphingosine 1-phosphate receptor 4

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EndoNet ID: ENR01319

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Synonyms

  • Sphingosine 1-phosphate receptor 4
  • Sphingosine 1-phosphate receptor Edg-6
  • edg6
  • S1PR4
  • Endothelial differentiation G-protein coupled receptor 6

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt O95977
Ensembl ENST00000246115

Subunit information

Subunit (1 times)

Sequence 
MNATGTPVA PESCQQLAA GGHSRLIVL 
HYNHSGRLA GRGGPEDGG LGALRGLSV 
AASCLVVLE NLLVLAAIT SHMRSRRWV 
YYCLVNITL SDLLTGAAY LANVLLSGA 
RTFRLAPAQ WFLREGLLF TALAASTFS 
LLFTAGERF ATMVRPVAE SGATKTSRV 
YGFIGLCWL LAALLGMLP LLGWNCLCA 
FDRCSSLLP LYSKRYILF CLVIFAGVL 
ATIMGLYGA IFRLVQASG QKAPRPAAR 
RKARRLLKT VLMILLAFL VCWGPLFGL 
LLADVFGSN LWAQEYLRG MDWILALAV 
LNSAVNPII YSFRSREVC RAVLSFLCC 
GCLRLGMRG PGDCLARAV EAHSGASTT 
DSSLRPRDS FRGSRSLSF RMREPLSSI 
SSVRSI
UniProt O95977-1

Binding hormones

  • sphingosine 1-phosphate
    • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). [1]
  • Sphingosylphosphorylcholine
    • All of the subsequently identified S1P receptors of the EDG family exhibited a low affinity for SPC and might thus rather mediate some of SPC's extracellular actions in the low micromolar concentration range. [2]

Anatomical structures with this receptor

  • lymphocyte

    Induced phenotypes

    • regulation of leukocyte migration
      • S1PR4 is the receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. [3]

  • lung

  • spleen

  • peripheral blood leukocytes

  • thymus

  • lymph_node

  • bone_marrow

  • appendix

  • liver

  • immune_system

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • regulation of T cell differentiation
      • S1P has been shown to modulate the polarizing functions of DCs on T cells when exposed to bacterial products. [4]
    • regulation of leukocyte migration
      • S1PR4 is dominantly expressed on mouse dendritic cells and has an important role in DC trafficking. [5]
    • dendritic cell chemotaxis
      • FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog. [6]

  • T-lymphocyte

    Induced phenotypes

    • negative regulation of interferon-gamma and interleukin-4 production
      • Signalling through S1PR4 in CD4+ T cells suppresses production of both cytokines, IFNgamma and IL-4, equally. [7]
    • positive regulation of interleukin-10 production
      • Signalling through S1PR4 in CD4+ T cells induces the production of IL-10. [7]
    • positive regulation of leukocyte migration
      • S1P has been reported to stimulate migration of T cells that express s1p4 under some conditions. T cell receptor-mediated activation of T cells suppresses expression of s1p4, and it has been reported to eliminate their migration responses to S1P. [8]

  • killer_T_cell

    Induced phenotypes

    • positive regulation of chemotaxis
      • S1P induces chemotaxis of thymocytes, T and B lymphocytes. [9]

  • keratinocyte

Reference