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Details for anatomical structure: nerve

EndoNet ID: ENC00088

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nerve, , Nervus

General information

A whitish cordlike structure composed of one or more bundles of myelinated or unmyelinated nerve fibers (or mixtures of both); coursing outside of the central nervous system

Links to other resources

Cytomer cy0043501

Larger structures


    • glial_cell_of_central_nervous_system
    • microglial_cell_in_central_nervous_system
    • oligodendrocyte
    • Purkinje_cell
    • Müllers_radial_cell_of_retina
    • bergmann_glia
    • smooth_muscle_cell
    • endothelial_cell
    • astrocyte
    • glial_cell_of_peripheral_nervous_system
    • macrophage
    • neuron
    • fibroblast
    • Schwann_cell

    Secreted hormones

    • Hormone: laminin gamma-3 chain

    • Hormone: CNTF

      • CNTF mRNA is widely expressed in the brain, heart, lung, liver, kidney and testis of the rat, in addition to preferential expression in the sciatic nerve. [1]
    • Hormone: laminin alpha-2 chain

    • Hormone: CGRP1

      Influenced by:

      • CB1
        in adrenal_gland
        • Stimulation of the CB1 receptor results in the inhibition of a range of excitatory and inhibitory neurotransmitters, like acetylcholine, noradrenaline, dopamine, 5-hydroxytryptamine, D-aspartate and cholecystokinin. [2]


    • Receptor: H1

    • Receptor: H2

    • Receptor: histamine H4 receptor

    • Receptor: IL-15R alpha

    • Receptor: Lysophosphatidic acid receptor 1

      Induced phenotype:

      • sensory perception of pain
        • Furthermore, Lpar1-deficient mice are resistant to neuropathic pain induced by partial sciatic nerve ligation. [3]
        • It was shown that LPA is able to initiate neuropathic pain in the peripheral nervous system, which occurs through the activation of LPA1 and subsequent release of the pronociceptive factor substance P. [4]