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Details for receptor: histamine H4 receptor

EndoNet ID: ENR00998

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  • H4
  • histamine H4 receptor
  • HH4R
  • GPRv53
  • G-protein coupled receptor 105
  • GPCR105
  • SP9144
  • AXOR35

General information

  • High expression on bone marrow and peripheral hematopoietic cells, eosinophils, neutrophils, DCs, T cells, basophils, mast cells, low expression in nerve cells, hepatocytes, peripheral tissues, spleen, thymus, lung, small intestine, colon and heart. [1]
  • Activated intracellular signals: enhanced Ca+2, inhibition of cAMP. [1]
  • The presence of the hH4R on leukocytes and mast cells suggests that this new histamine receptor plays an important role in the modulation of the immune system. [2]
  • IL-10 and IL-13 modulate hH4R expression and that binding sites for cytokine-regulated transcription factors [2]
  • The histamine H4 receptor is involved in the chemotaxis of leukocytes and mast cells to sites of inflammation and is suggested to be a potential drug target for asthma and allergy. [2]

Links to other resources

UniProt Q9H3N8
Ensembl ENST00000426880

Binding hormones

  • histamine

Anatomical structures with this receptor

  • mast_cell

  • leukocyte

  • bone_marrow

  • eosinophil_granulocyte

  • neutrophil_granulocyte

  • dendritic_cell_in_lymphoid_tissues

  • basophil_granulocyte

  • nerve

  • hepatocyte

  • spleen

  • thymus

  • lung

  • small_intestine

  • colon

  • heart

  • T-lymphocyte