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Details for anatomical structure: fibroblast

EndoNet ID: ENC00283

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Synonyms

fibroblast, , Fibroblastocytus

General information

A cell deriving from the mesenchym, very active in secretion of extracellular matrix fiber; when metabolic decreases the cell transforms a fibrocyt

Links to other resources

Cytomer cy0011522

Larger structures

  • brain
  • peripheral_nerve_system_element
  • heart
  • gonads
  • nasal_mucosa
  • pituitary_gland_of_diencephalon
  • ovary
  • large_intestine
  • lung
  • muscle
  • skin
  • tonsil
  • immune_system
  • uterus
  • liver
  • pancreas
  • atrium_of_heart
  • pulmonary_vessels
  • stomach
  • cerebellum
  • eye
  • chorion
  • bone_marrow
  • skeleton_muscle
  • circulatory_system__hematopoietic_system
  • parts_of_human_body
  • urinary_bladder
  • oesophagus
  • nerve
  • trachea
  • mammary_gland
  • eccrine_gland
  • bronchi
  • growth_plate
  • lymph_node
  • breast
  • cartilage
  • adenohypophysis
  • spleen
  • major_salivary_glands
  • spinal_cord
  • bone
  • internal_ear
  • smooth_muscle
  • D_cell_of_gastrointestinal_tract
  • blood_vessel
  • propria_mucosa_of_bronchus
  • small_intestine
  • gallbladder
  • umbilical_cord
  • mucosa_of_gastric_wall
  • testis
  • central_nerve_system_element
  • thyroid_gland
  • digestive_system
  • thymus
  • lymphoid_tissue
  • caecum
  • adrenal_gland
  • prostate
  • dorsal_root_ganglion

Substructures

    Secreted hormones

    • Hormone: GROalpha

    • Hormone: PGE2

      • The CD40-CD40L interaction has been shown to stimulate prostaglandin and IL-8 release from fibroblasts. [1]

    • Hormone: IL-8

      • The CD40–CD40L interaction has been shown to stimulate prostaglandin and IL-8 release from fibroblasts. [1]

    • Hormone: GM-CSF

    • Hormone: M-CSF

    • Hormone: G-CSF

    • Hormone: IFN-beta

    • Hormone: eotaxin

      • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

    • Hormone: fibromodulin

    • Hormone: decorin

    • Hormone: thrombospondin 1

    • Hormone: tenascin-C

    • Hormone: gremlin-1

    • Hormone: WISP-2

    • Hormone: CTGF

    • Hormone: CYR61

    • Hormone: IL-20

    • Hormone: SDF-1alpha

    • Hormone: SDF-1beta

    • Hormone: PTHLH

    • Hormone: FGF-7

      Influenced by:

      • ER-beta
        in fibroblast
        • ER-beta variants, including ER-beta 1, ER-beta 2, ER-beta 5, ER-betadelta and ER-betains, but not ER-alpha, are expressed in human adult mammary fibroblasts. An ER-beta-selective ligand, BAG, but not the ER-alpha high-affinity ligand oestradiol, can induce fibroblast growth factor-7 release in adult human mammary fibroblasts. [3]

    • Hormone: TGF-beta 2

    • Hormone: PDGFB

    • Hormone: FGF-1 isoform 1

    • Hormone: FGF-2

    • Hormone: FGF-2

    • Hormone: pregnancy-associated plasma protein A

    • Hormone: PAI-2

    • Hormone: Dynamin-2

    • Hormone: cathepsin L

      • Both the synthesis and secretion of MEP are dramatically increased in response to tumor promoters, certain growth factors, and viral transformation. [4]
      • Although the biological function of secreted MEP is not known, the patterno f its regulation by growth factors and transforming agents suggests that it plays some important role in the growth of normal and transformed cells. [5]

    • Hormone: angiotensin II

      Influenced by:

      • angiotensin II type 1 receptor
        in fibroblast
        • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]

    • Hormone: FGF-2

    • Hormone: interleukin 6

      • Fibroblast secretion of biologically active IL-6 has been reported in response to stimulation with both TNFa and IL-lalpha. [7]

    Receptors

    • Receptor: activin receptor type I

    • Receptor: MC1R

      Induced phenotype:

      • suppression of interstitial fibrosis
        • Alpha-MSH suppressed interstitial fibrosis induced by TGF-beta1 and reduced the number of vimentin and alpha-smooth muscle actin positive cells. [8]

    • Receptor: BMP receptor type II

    • Receptor: MRC2

    • Receptor: integrin beta-1

    • Receptor: IL-15R alpha

    • Receptor: ER-beta

      Influences:

      • FGF-7
        • ER-beta variants, including ER-beta 1, ER-beta 2, ER-beta 5, ER-betadelta and ER-betains, but not ER-alpha, are expressed in human adult mammary fibroblasts. An ER-beta-selective ligand, BAG, but not the ER-alpha high-affinity ligand oestradiol, can induce fibroblast growth factor-7 release in adult human mammary fibroblasts. [3]

    • Receptor: angiotensin II type 1 receptor

      Influences:

      • angiotensin II
        • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]
      • angiotensin II
        • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]

    • Receptor: Sphingosine 1-phosphate receptor 1

    • Receptor: Lysophosphatidic acid receptor 1

      Induced phenotype:

      • wound healing
        • Several lines of evidence suggest that LPA mediates wound healing.
        • LPA induced the closure of wounded endothelial monolayers in vitro. [9]
        • In vivo LPA application promoted repair processes in cutaneous wounds. [10]
        • In vivo LPA application promoted repair processes in intestinal wounds. [11]
        • Migration of fibroblasts into the fibrin wound matrix is an essential step in the wound-healing process in injured tissues, and LPA1 signaling regulates migration of mouse embryonic fibroblasts. [12]

    • Receptor: PDGFRalpha

      • Cardiac fibroblasts express PDGFR-alpha. [13]

      Induced phenotype:

      • proliferation of fibroblasts
        • PDGF-C, which binds to and activates the PDGF alpha-receptor, is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. [13]
    Reference