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Details for messenger / hormone: angiotensinogen

EndoNet ID: ENH00082

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Synonyms

  • angiotensinogen
  • AGT
  • SERPINA8

General information

  • The expression of AGT is nutritionally and hormonally regulated in adipose tissue. [1]
  • Angiotensinogen expression is increased in obesity. [2]
  • AGT regulates blood pressure. [3]
  • In the classical RAS, circulating renal-derived renin cleaves angiotensinogen, a protein principally synthesized in the liver, to form the decapeptide angiotensin I, an inactive substance. [1]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • genome-encoded
        • serpin family

      Composition

      Sequence 
      MRKRAPQSE MAPAGVSLR ATILCLLAW 
AGLAAGDRV YIHPFHLVI HNESTCEQL 
AKANAGKPK DPTFIPAPI QAKTSPVDE 
KALQDQLVL VAAKLDTED KLRAAMVGM 
LANFLGFRI YGMHSELWG VVHGATVLS 
PTAVFGTLA SLYLGALDH TADRLQAIL 
GVPWKDKNC TSRLDAHKV LSALQAVQG 
LLVAQGRAD SQAQLLLST VVGVFTAPG 
LHLKQPFVQ GLALYTPVV LPRSLDFTE 
LDVAAEKID RFMQAVTGW KTGCSLMGA 
SVDSTLAFN TYVHFQGKM KGFSLLAEP 
QEFWVDNST SVSVPMLSG MGTFQHWSD 
IQDNFSVTQ VPFTESACL LLIQPHYAS 
DLDKVEGLT FQQNSLNWM KKLSPRTIH 
LTMPQLVLQ GSYDLQDLL AQAELPAIL 
HTELNLQKL SNDRIRVGE VLNSIFFEL 
EADEREPTE STQQLNKPE VLEVTLNRP 
FLFAVYDQS ATALHFLGR VANPLSTA

      Links to other resources

      UniProt P01019
      Ensembl ENST00000430091
      KEGG hsa:183

      • Anatomical structure: fat_cell

        • Esxpression is increased in obese state. [3]

      • Anatomical structure: adipose_tissue

      • Anatomical structure: lipocyte_of_liver

      • Anatomical structure: hepatocyte

        • Freshly isolated human hepatocytes expressed higher levels of angiotensinogen and lower levels of renin and ACE compared with activated HSCs. [4]
        • Hepatocytes are the main source of angiotensinogen in the human liver. [4]

        Influenced by:

        • angiotensin II type 1 receptor
          in hepatocyte
          • Angiotensin II stimulates the hepatic synthesis and secretion of angiotensinogen, the substrate of renin. This effect is mainly related to a transient inhibition of adenylylcyclase. [5]

      Targets

      Cellangiotensin II type 1 receptor
      adipose tissue Present
      Phenotypes
      • differentiation of preadipocytes
      • positive regulation of lipid metabolic process
      • regulation of lipid metabolic process
      adrenal cortex Present
      Phenotypes
      • positive regulation of renal sodium ion absorption
      adrenal gland Present
      blood vessel Present
      brain Present
      Phenotypes
      • regulation of blood pressure
      cardiac myocyte Present
      cell of adrenal gland zona glomerulosa Present
      Phenotypes
      • positive regulation of phospholipid catabolic process
      Influences
      • ↑ aldosterone
      circulatory system hematopoietic system Present
      Phenotypes
      • regulation of vasoconstriction
      • angiogenesis
      • vasoconstriction
      • regulation of vascular smooth muscle cell proliferation
      corpus luteum Present
      fibroblast Present
      Influences
      • ↑ angiotensin II
      • ↑ angiotensin II
      Goormaghtighs cell Present
      Influences
      • ↓ renin
      granulosa cell Present
      Phenotypes
      • regulation of angiogenesis
      heart Present
      hepatocyte Present
      Influences
      • ↑ angiotensinogen
      kidney Present
      Phenotypes
      • salt and fluid balance
      • renal water reabsorption
      • blood pressure increase
      • negative regulation of natriuresis
      • regulation of blood pressure
      lipocyte of liver Present
      Influences
      • ↓ TGF-beta 1
      • angiotensin II
      lung Present
      ovary Present
      Phenotypes
      • steroidogenesis
      • angiogenesis
      • ovarian follicle development
      Influences
      • angiotensin II
      proximal tubule of nephron Present
      Influences
      • ↑ angiotensin II
      • ↑ angiotensin II
      tertiary follicle Present
      theca cell Present
      theca lutein cell Present
      Reference