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Details for messenger / hormone: TGF-beta 2

EndoNet ID: ENH00213

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  • Cetermin
  • Polyergin
  • BSC-1 cell growth inhibitor
  • glioblastoma-derived T-cell suppressor factor
  • Polyergin
  • BSC-1 cell growth inhibitor
  • glioblastoma-derived T-cell suppressor factor
  • transforming growth factor beta-2
  • TGF-beta 2
  • transforming growth factor beta 2

General information

  • TGF-betas are important growth suppressing factors in normal breast epithelium and their activity is mediated by specific receptors, including TGF-beta-RII. [1]
  • TGF-beta-mediated epithelial-mesenchymal transition of mammary epithelial cells is accompagnied by the loss of laminin-5 production and the upregulation of fibronectin and its alpha-5/beta-1 integrin receptor. [2]
  • TGF-beta2 binds to TbetaRIII, which then recruits TbetaRII and TbetaRI resulting in phosphorylation of TbetaRI and downstream signaling. [3]


Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • TGF-beta family

        Links to other resources

        UniProt P08112
        Ensembl ENST00000366930
        KEGG hsa:7042
        • Anatomical structure: osteoblast

          • In osteoblasts, TGF-beta 2 gene transcription is increased by 1alpha,25(OH)2D3. [4]
          • Osteoblasts expresses mRNA transcripts of TGF-beta1, TGF-beta2, TGF-beta 3, TGF-beta type I and type II receptors. [5]

          Influenced by:

          • VDR
            in osteoblast
        • Anatomical structure: cell_of_endometrium_of_uterus

          • TGF-beta 2 treatment in vitro acts directly on isolated endometrial epithelial cells, independently suppressing promatrilysin protein expression. [6]
          • TGF-beta 2 appears to increase expression of all three mammalian isotypes (TGF-beta 1,2,3). [6]
          • In women, expression of TGF-b1, -b2 and -b3 and the type II receptor occurs in all cell types of the endometrium. [7]
          • Within the stroma, TGF-b2 expression increases during the secretory phase. [7]
          • TGF-b2 is the progesterone- induced, stromal-derived paracrine factor that suppresses epithelial matrilysin production. [7]

          Influenced by:

          • progesterone receptor
            in cell_of_endometrium_of_uterus
            • Northern blot analysis confirmed an increase in TGF-beta 2 mRNA with progesterone treatment. [6]
        • Anatomical structure: fibroblast

        • Anatomical structure: adrenal_gland

          • TGF-β isoform 2 is synthesized by cells in the wall of the dorsal aorta as well as at later stages in both cortical and migrating chromaffin cells within the developing adrenal gland. [8]


        CellTGF-beta type II receptorTGFR-3vasorin
        adrenal cortex Present
        aorta Present
        brain Present
        cell of endometrium of uterus Present
        • TGF-beta 1
        • LIF
        • interleukin 6
        dendritic cell in lymphoid tissues follicular Present
        heart Present
        kidney Present
        lung Present
        mammary gland Present
        osteoblast Present
        placenta Present
        skeleton muscle Present
        smooth muscle cell Present
        • negative regulation of transforming growth factor beta receptor signaling pathway
        • TGF-beta 1
        umbilical cord Present
        umbilical vein Present
        umbilical vein endothelial cells Present