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Details for messenger / hormone: Wnt-2

EndoNet ID: ENH00478

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Synonyms

  • int-1-like protein 1
  • protein Wnt-2
  • Wnt-2
  • WNT2
  • IRP protein
  • int-1-related protein
  • wingless-type MMTV integration site family member 2

General information

  • All Wnts contain 23-24 cysteine residues. [1]
  • Member of the Wnt1 class (inducers of secondary body axis in Xenopus), which facilitates Fzd and Lrp interactions and activates the canonical Wnt/beta-catenin pathway. [1]
  • Optimal Wnt signaling also requires association with glycosaminoglycans (e.g. heparin sulfate and chondroitin sulfate) in the extracellular matrix. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • Wnt family

      Composition

      Sequence 
      SWWYMRATG GSSRVMCDN VPGLVSSQR 
QLCHRHPDV MRAISQGVA EWTAECQHQ 
FRQHRWNCN TLDRDHSLF GRVLLRSSR 
ESAFVYAIS SAGVVFAIT RACSQGEVK 
SCSCDPKKM GSAKDSKGI FDWGGCSDN 
IDYGIKFAR AFVDAKERK GKDARALMN 
LHNNRAGRK AVKRFLKQE CKCHGVSGS 
CTLRTCWLA MADFRKTGD YLWRKYNGA 
IQVVMNQDG TGFTVANER FKKPTKNDL 
VYFENSPDY CIRDREAGS LGTAGRVCN 
LTSRGMDSC EVMCCGRGY DTSHVTRMT 
KCGCKFHWC CAVRCQDCL EALDVHTCK 
APKNADWTT AT

      Links to other resources

      UniProt P09544
      Ensembl ENST00000265441
      KEGG hsa:7472

        Targets

        Cellfrizzled 1
        heart Present
        kidney Present
        lung Present
        ovary Present
        pancreas Present
        pancreatic islets Present
        placenta Present
        prostate Present
        thyroid gland Present
        Reference