Status
Please wait ...

Details for messenger / hormone: Wnt-3

EndoNet ID: ENH00479

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • proto-oncogene Int-4 homolog
  • proto-oncogene Wnt-3
  • WNT3
  • wnt 3
  • Wnt3
  • proto-oncogene protein Wnt-3
  • INT4
  • wingless-type MMTV integration site family member 3
  • Wnt-3

General information

  • Optimal Wnt signaling also requires association with glycosaminoglycans (e.g. heparin sulfate and chondroitin sulfate) in the extracellular matrix. [1]
  • Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. [2]
  • Member of the Wnt1 class (inducers of secondary body axis in Xenopus), which facilitates Fzd and Lrp interactions and activates the canonical Wnt/beta-catenin pathway. [1]
  • All Wnts contain 23-24 cysteine residues. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • Wnt family

      Composition

      Sequence 
      GYPIWWSLA LGQQYTSLG SQPLLCGSI 
PGLVPKQLR FCRNYIEIM PSVAEGVKL 
GIQECQHQF RGRRWNCTT IDDSLAIFG 
PVLDKATRE SAFVHAIAS AGVAFAVTR 
SCAEGTSTI CGCDSHHKG PPGEGWKWG 
GCSEDADFG VLVSREFAD ARENRPDAR 
SAMNKHNNE AGRTTILDH MHLKCKCHG 
LSGSCEVKT CWWAQPDFR AIGDFLKDK 
YDSASEMVV EKHRESRGW VETLRAKYS 
LFKPPTERD LVYYENSPN FCEPNPETG 
SFGTRDRTC NVTSHGIDG CDLLCCGRG 
HNTRTEKRK EKCHCIFHW CCYVSCQEC 
IRIYDVHTC K

      Links to other resources

      UniProt P56703
      Ensembl ENST00000225512
      KEGG hsa:7473

      • Anatomical structure: spinal_cord

      • Anatomical structure: alar_column

      • Anatomical structure: anterior_horn_of_spinal_cord

        • In the spinal cord Wnt-3 was expressed at low levels in the alar laminae and in the ventral horns. [2]

      • Anatomical structure: hippocampus

      • Anatomical structure: medulla_oblongata

      • Anatomical structure: cerebellum

      • Anatomical structure: superior_colliculus

      Targets

      Cellfrizzled 1
      heart Present
      kidney Present
      lung Present
      ovary Present
      pancreas Present
      pancreatic islets Present
      placenta Present
      prostate Present
      thyroid gland Present
      Reference