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Details for messenger / hormone: WNT3A

EndoNet ID: ENH00480

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Synonyms

  • Wnt3a
  • wnt 3a
  • wnt 3A
  • WNT3A
  • Wnt-3a
  • protein Wnt-3a
  • wingless-type MMTV integration site family member 3a

General information

  • Wnt3a regulates casein kinase 2 activity. [1]
  • Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. [2]
  • All Wnts contain 23-24 cysteine residues. [3]
  • Wnt3a is palmitoylated on a conserved cysteine, and removal of this palmitate or mutation of this cysteine result in lost of activity. [4]
  • Optimal Wnt signaling also requires association with glycosaminoglycans (e.g. heparin sulfate and chondroitin sulfate) in the extracellular matrix. [3]
  • Member of the Wnt1 class (inducers of secondary body axis in Xenopus), which facilitates Fzd and Lrp interactions and activates the canonical Wnt/beta-catenin pathway. [3]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • Wnt family

      Composition

      Protein Wnt-3a

      Sequence 
      SLAVGPQYS SLGSQPILC ASIPGLVPK 
QLRFCRNYV EIMPSVAEG IKIGIQECQ 
HQFRGRRWN CTTVHDSLA IFGPVLDKA 
TRESAFVHA IASAGVAFA VTRSCAEGT 
AAICGCSSR HQGSPGKGW KWGGCSEDI 
EFGGMVSRE FADARENRP DARSAMNRH 
NNEAGRQAI ASHMHLKCK CHGLSGSCE 
VKTCWWSQP DFRAIGDFL KDKYDSASE 
MVVEKHRES RGWVETLRP RYTYFKVPT 
ERDLVYYEA SPNFCEPNP ETGSFGTRD 
RTCNVSSHG IDGCDLLCC GRGHNARAE 
RRREKCRCV FHWCCYVSC QECTRVYDV 
HTCK
      UniProt P56704

      Links to other resources

      UniProt P56704
      Ensembl ENST00000366753
      KEGG hsa:89780

      • Anatomical structure: roof_plate_of_neural_tube

        • Wnt-3A expression was confined to the roof plate. [2]

      • Anatomical structure: ectoderm

      • Anatomical structure: brain

      Targets

      Cellfrizzled 1
      heart Present
      kidney Present
      lung Present
      ovary Present
      pancreas Present
      pancreatic islets Present
      placenta Present
      prostate Present
      thyroid gland Present
      Reference