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Details for messenger / hormone: VEGFB

EndoNet ID: ENH00514

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Synonyms

  • VEGF-B Isoform 1
  • VEGF-related factor
  • VRF
  • VEGFB
  • vascular endothelial growth factor B

General information

  • VEGF-B167 binds heparan sulfate proteoglycans and is mostly sequestered in the extracellular matrix while VEGF-B186 is freely diffusible. [1]
  • Expressed in all tissues except liver, highest levels in heart, skeletal muscle and pancreas. [2]
  • The VEGF-B167 isoform is mainly expressed in the most tissues including skeletal muscles, myocardium and brown fat and accounts for more than 80% of the total VEGF-B transcripts. [1]
  • The VEGF-B186 isoform is expressed at lower levels and only in a limited number of tissues. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • PDGF/VEGF growth factor family

      Composition

      VEGF-B186 (2 times)

      • Homodimer, can also form heterodimer with VEGF-A. [2]
      Sequence 
      PVSQPDAPG HQRKVVSWI DVYTRATCQ 
PREVVVPLT VELMGTVAK QLVPSCVTV 
QRCGGCCPD DGLECVPTG QHQVRMQIL 
MIRYPSSQL GEMSLEEHS QCECRPKKK 
DSAVKPDRA ATPHHRPQP RSVPGWDSA 
PGAPSPADI THPTPAPGP SAHAAPSTT 
SALTPGPAA AAADAAASS VAKGGA
      UniProt P49765-1

      Links to other resources

      UniProt P49765
      Ensembl ENST00000309422
      KEGG hsa:7423

      • Anatomical structure: heart

        • Expressed in almost all tissues with the highest amounts in heart, pancreas and skeletal muscle. Not expressed in liver.

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: pancreas

      Targets

      Cellneuropilin 1sVEGF-R1Vascular endothelial growth factor receptor 1
      blood vessel Present
      Phenotypes
      • excess of capillary formation
      • patterning of blood vessels
      bone marrow Present
      		Present
      Phenotypes
      • hematopoiesis
      brain Present
      Phenotypes
      • axon guidance
      		Present
      		Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      • positive regulation of endothelial cell proliferation
      • positive regulation of endothelial cell migration
      • inflammation
      Influences
      • ↑ interleukin 6
      glomerulus Present
      Phenotypes
      • induction of podocyte apoptosis
      • formation of glomerular filter barrier
      • inhibition of glomerular capillary lumen development
      • patterning of blood vessels
      • positive regulation of apoptosis
      heart Present
      Phenotypes
      • patterning of blood vessels
      		Present
      		Present
      Phenotypes
      • heart development
      kidney Present
      Phenotypes
      • inhibition of ureteric bud branching
      • excess of endothelial cells
      • podocyte differentiation
      • cell differentiation
      • acute nephrotic range proteinuria
      		Present
      		Present
      lung Present
      		Present
      		Present
      mammary gland Present
      Müllers radial cell of retina Present
      Phenotypes
      • regulation of neural retina development
      pancreas Present
      placenta Present
      		Present
      		Present
      Phenotypes
      • preeclampsia
      podocyte Present
      sinusoidal endothelial cell Present
      Phenotypes
      • negative regulation of apoptosis
      skeleton muscle Present
      smooth muscle Present
      Phenotypes
      • vessel maturation
      vascularendothelial cell Present
      		Present
      Phenotypes
      • vasculogenesis
      • vascular permeability
      Reference